ArticleCell cycle (Georgetown, Tex.)2006
The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities.
Article in Cell cycle (Georgetown, Tex.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- An in vitro tumor recurrence model based on platinum-resistant colon cancer cells as a research tool for studying cancer cell dormancy.PloS one · 2025Article
- Bone niches in the regulation of tumour cell dormancy.Journal of bone oncology · 2024Article
- Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy.Cold Spring Harbor perspectives in medicine · 2020Review
- The current paradigm and challenges ahead for the dormancy of disseminated tumor cells.Nature cancer · 2020Review
- A cancer amidst us: the plexiform lesion in pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Tumor cell-organized fibronectin maintenance of a dormant breast cancer population.Science advances · 2020Article
- Effects of PTEN Loss and Activated KRAS Overexpression on Mechanical Properties of Breast Epithelial Cells.International journal of molecular sciences · 2018Article
- The Relationship Between Regional Anesthesia and Cancer: A Metaanalysis.Ochsner journal · 2017Review
- Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1).Acta crystallographica. Section F, Structural biology communications · 2017Article
- Developing multi-target therapeutics to fine-tune the evolutionary dynamics of the cancer ecosystem.Frontiers in pharmacology · 2015Article
- Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition.Breast cancer research and treatment · 2014Article
- Bisphosphonates in the adjuvant treatment of young women with breast cancer: the estrogen rich is a poor candidate!Journal of thoracic disease · 2013Article
- Modeling boundary conditions for balanced proliferation in metastatic latency.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Impact of deleterious passenger mutations on cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage?Journal of ovarian research · 2013Article
- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies.World journal of stem cells · 2011Article
- Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Lung cancer stem cell: new insights on experimental models and preclinical data.Journal of oncology · 2011Article
- Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy?Cancers · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The hiatus observed in the progression of cancer after diagnosis and treatment in a large proportion of patients has led to the notion that a state of cancer dormancy must exist during tumor progression. However, research on this stage of cancer has been limited due to the lack of appropriate models and clinical correlates. Fortunately, the last decade has seen the development of new cancer dormancy models, whole animal and intravital imaging techniques and the molecular characterization of minimal residual disease. These studies enabled researchers to reveal intriguing mechanisms and molecular determinants that define tumor dormancy. It is imperative to understand the basic mechanisms of dormancy, as this will accelerate the development of new markers of progression and novel therapeutic opportunities to induce dormancy and/or eradicate dormant disease. This issue of Cell Cycle includes a "Spotlight on Cancer Dormancy" highlighting major contributions to the field of cancer dormancy from basic and clinical studies. We anticipate that this will initiate a forum of discussion on the problem of cancer dormancy and stimulate investigators to study this rather unexplored but undeniably relevant clinical stage of cancer progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.