ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed, 260 citations in OpenAlex.
- Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026Article
- Cryo-EM structures of Drosophila OR67d-Orco complexes reveal insect pheromone sensing mechanism.Cell research · 2026Article
- Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.Current biology : CB · 2026Article
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- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins.bioRxiv : the preprint server for biology · 2025Article
- Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins.Research square · 2025Article
- The Ortholog Receptor Or67d in Drosophila Bipectinata is able to Detect Two Different Pheromones.Journal of chemical ecology · 2024Article
- Stimulus duration encoding occurs early in the moth olfactory pathway.Communications biology · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila.Neuroscience bulletin · 2023Article
- Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Identification and expression profile analysis of chemosensory genes in pine needle gall midge,Frontiers in physiology · 2023Article
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73 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Insect pheromones elicit stereotypic behaviors that are critical for survival and reproduction. Defining the relevant molecular mechanisms mediating pheromone signaling is an important step to manipulate pheromone-induced behaviors in pathogenic or agriculturally important pests. The only volatile pheromone identified in Drosophila is 11-cis-vaccenyl acetate (VA), a male-specific lipid that mediates aggregation behavior. VA activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies. Here, we identify a neuronal receptor required for VA sensitivity. We identified two mutants lacking functional T1 sensilla and show that the expression of the VA receptor is dramatically reduced or eliminated. Importantly, we show misexpression of this receptor in non-T1 neurons, normally insensitive to VA, confers pheromone sensitivity at physiologic concentrations. Sensitivity of T1 neurons to VA requires LUSH, an extracellular odorant-binding protein (OBP76a) present in the sensillum lymph bathing trichoid olfactory neuron dendrites. Here, we show LUSH are also required in non-T1 neurons misexpressing the receptor to respond to VA. These data provide new insight into the molecular components and neuronal basis of volatile pheromone perception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.