ArticleThorax2007
Surgery for patients with drug-resistant tuberculosis: report of 121 cases receiving community-based treatment in Lima, Peru.
Article in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 89 citations in OpenAlex.
- The incidence of tuberculous pleurisy in mainland China from 2005 to 2018.Frontiers in public health · 2023Article
- A case report of persistent drug-sensitive pulmonary tuberculosis after treatment completion.BMC infectious diseases · 2022Article
- Managing severe tuberculosis and its sequelae: from intensive care to surgery and rehabilitation.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2019Review
- Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019Article
- Post-resection complications: abscesses, empyemas, bronchopleural fistulas.Journal of thoracic disease · 2018Review
- Pulmonary resection in the treatment of multidrug-resistant tuberculosis: A case series.Medicine · 2017Article
- Cost-effectiveness of adding novel or group 5 interventions to a background regimen for the treatment of multidrug-resistant tuberculosis in Germany.BMC health services research · 2017Article
- Clinical outcomes for multi- and extensively drug resistant tuberculosis patients with adjunctive resectional lung surgery in Beijing, China.Journal of thoracic disease · 2017Article
- Role of Surgery in the Diagnosis and Management of Tuberculosis.Microbiology spectrum · 2017Review
- Surgical interventions for pulmonary tuberculosis in Mumbai, India: surgical outcomes and programmatic challenges.Public health action · 2016Article
- Surgery and pleuro-pulmonary tuberculosis: a scientific literature review.Journal of thoracic disease · 2016Review
- Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis.Cold Spring Harbor perspectives in medicine · 2015Review
- Favorable outcomes for multidrug and extensively drug resistant tuberculosis patients undergoing surgery.The Annals of thoracic surgery · 2013Article
- Aggressive regimens for multidrug-resistant tuberculosis reduce recurrence.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Aggressive regimens for multidrug-resistant tuberculosis decrease all-cause mortality.PloS one · 2013Article
- Surgical treatment of drug-resistant tuberculosis.The Lancet. Infectious diseases · 2012Review
- Comprehensive treatment of extensively drug-resistant tuberculosis.The New England journal of medicine · 2008Article
- Article
- Multidrug-resistant tuberculosis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile most patients with tuberculosis (TB) can be successfully treated using short-course medical chemotherapy, thoracic surgery is an important adjunctive strategy for many patients with drug-resistant disease. The need for physical, technical and financial resources presents a potential challenge to implementing surgery as a component of treatment for multidrug-resistant TB (MDR-TB) in resource-poor settings. However, a cohort of patients with severe MDR-TB in Lima, Peru underwent surgery as part of their treatment.
methods121 patients underwent pulmonary surgery for drug-resistant tuberculosis between May 1999 and January 2004. Surgery was performed by a team of thoracic surgeons under the Ministry of Health. Patient demographic data, clinical characteristics, surgical procedures and surgical outcomes were studied.
resultsMost of the patients had failed multiple TB regimens and were resistant to a median of seven drugs. The median time of follow-up after surgery was 33 months. 79.3% of patients were culture-positive before surgery, and sustained culture-negative status among survivors was achieved in 74.8% of patients. 63% of those followed up for at least 6 months after surgery were either cured or probably cured. Postoperative complications, observed in 22.6% of patients, were associated with preoperative haemoptysis, vital capacity <50% and low forced expiratory volume in 1 s.
conclusionsThis is one of the largest cohorts with MDR-TB to be treated with surgery, and the first from a resource-poor country. Although surgery is not often considered an option for patients in resource-poor settings, the findings of this study support the argument that adjunctive surgery should be considered an integral component of MDR-TB treatment programmes, even in poor countries such as Peru.
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