ArticleDigestive diseases and sciences2006
The effect of melatonin on TNBS-induced colitis.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.NPJ biofilms and microbiomes · 2024Review
- Protective effect of (E)-(2,4-dihydroxy)-α-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS.Bioscience reports · 2024Article
- Docosahexaenoic acid (DHA) alleviates inflammation and damage induced by experimental colitis.European journal of nutrition · 2024Article
- Puerarin alleviates sleep disorders in aged mice related to repairing intestinal mucosal barrier.Natural products and bioprospecting · 2023Article
- Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats.Scientific reports · 2022Article
- Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice.Journal of microbiology (Seoul, Korea) · 2020Article
- Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation.Intestinal research · 2020Article
- Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.Scientific reports · 2020Article
- Melatonin modulates adiponectin expression on murine colitis with sleep deprivation.World journal of gastroenterology · 2016Article
- Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Melatonin improves experimental colitis with sleep deprivation.International journal of molecular medicine · 2015Article
- Sleep disorders and inflammatory disease activity: chicken or the egg?The American journal of gastroenterology · 2015Article
- Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis.Digestive diseases and sciences · 2014Article
- Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms.Digestive diseases and sciences · 2013Article
- The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat.Digestive diseases and sciences · 2013Article
- Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis.World journal of gastroenterology · 2013Article
- Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.International journal of molecular sciences · 2013Review
- Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats.Digestive diseases and sciences · 2012Article
- Distribution, function and physiological role of melatonin in the lower gut.World journal of gastroenterology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ulcerative colitis is a multifactorial inflammatory disease of the colon and rectum with an unknown etiology. The present study was undertaken to investigate the effect of melatonin administration on oxidative damage and apoptosis in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Rats were divided into four groups as follows: Group 1 (n=8)-T-NBS colitis; Group 2 (n=8)--melatonin, 10 mg/kg/day ip, for 15 days in addition to TNBS; Group 3 (n=8)--melatonin alone, 10 mg/kg/day ip, for 15 days; and Group 4 (n=8)-isotonic saline solution, 1 ml/rat ip, for 15 days (sham control group). Colonic myeloperoxidase (MPO) activities, malondialdehyde (MDA) levels, and glutathione (GSH) levels are indicators of oxidative damage, while caspase-3 activities reveal the degree of apoptosis of the colonic tissue. In all TNBS-treated rats, colonic MPO activity and MDA levels were found to be increased significantly compared to those in the sham group. Colonic MPO activity and MDA levels were significantly lower in the melatonin treatment group compared to TNBS-treated rats. GSH levels of colonic tissues were found to be significantly lower in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly increased GSH levels compared to those in TNBS-treated rats. Caspas-3 activity of colonic tissues was found to be significantly higher in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly decreased caspase-3 activity compared to that in TNBS-treated rats. These results imply a reduction in mucosal damage due to anti-inflammatory and anti-apoptotic effects of melatonin.
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