Evidence map›Paper›PMID 16927129›Full record

ArticleVirus genes2007

Herpes simplex virus type 1 shows multiple interactions with sulfonated compounds at binding, penetration, and cell-to-cell passage.

José Santiago Aguilar, Katherine S Held, Edward K Wagner

Abstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Virus genes, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

José Santiago AguilarDepartment of Molecular Biology and Biochemistry, Center for Virus Research, University of California, Irvine, CA 92697, USA. jsaguila@uci.edu
Katherine S Held
Edward K Wagner
University of California, Irvine · US

Funding

CONTROL OF VIRAL RNA SYNTHESIS IN HERPESVIRUS INFECTIONR01CA011861 · NCI · UNIVERSITY OF CALIFORNIA IRVINE · PI OSBORNE, TIMOTHY F · 1985 to 2005
$1.9M
DNA Microarrays for Neurotropic Human HerpesvirusesR01CA090287 · NCI · UNIVERSITY OF CALIFORNIA IRVINE · PI OSBORNE, TIMOTHY F · 2001 to 2004
$1.2M
CONTROL OF VIRAL RNA SYNTHESIS IN HERPESVIRUS INFECTIONR37CA011861 · NCI · UNIVERSITY OF CALIFORNIA IRVINE · PI WAGNER, EDWARD K · 1988 to 1995
–
NCI NIH HHS CA11861NCI NIH HHS CA90287
6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) uses multicomponent mechanisms for binding, penetration, and cell-to-cell passage. These processes are affected by polysulfonated compounds. In this paper we have addressed the question of whether the same or different interactions of HSV-1 with polysulfonated compounds are involved in binding, penetration, and passage. For this, we have compared the inhibitory dose-response for a series of polysulfonated and cationic compounds known to block HSV-1 infections. These comparisons were done at the level of binding, penetration, and cell-to-cell passage. Variations in the parameters of the dose-response curves - IC(50) and Hill coefficients (n (H)) - are consistent with HSV-1 having multiple interactions with sulfonated cellular components in all these processes. Some of the interactions seem to be common to the three processes, while others are particular for each one.

Indexed as

AnimalsCell CommunicationCells, CulturedChlorocebus aethiopsDrug CombinationsDrug InteractionsHerpesvirus 1, HumanRabbitsSulfonium CompoundsVero CellsVirus AttachmentVirus InternalizationDrug CombinationsSulfonium Compounds

Identifiers

PMID16927129
OpenAlexW2053576014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.