ArticleAnnals of surgery2006
Parenteral nutrition impairs gut-associated lymphoid tissue and mucosal immunity by reducing lymphotoxin Beta receptor expression.
Article in Annals of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Electromagnetic-guided versus endoscopic-guided postpyloric placement of nasoenteral feeding tubes.The Cochrane database of systematic reviews · 2022Pooled it
- Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans.Shock (Augusta, Ga.) · 2012Trial
- Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure.Critical care medicine · 2011Trial
- Continuous extracorporeal chyme reinfusion using the veraflo system in open abdomen with duodenostomy: a case report.BMC surgery · 2026Article
- Farnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot.Nutrients · 2024Review
- Breastfeeding Contributes to Physiological Immune Programming in the Newborn.Frontiers in pediatrics · 2021Review
- The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.The journal of trauma and acute care surgery · 2017Article
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- The gastrointestinal immune system: Implications for the surgical patient.Current problems in surgery · 2016Review
- The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition.Annals of surgery · 2014Article
- Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Parenteral nutrition impairs lymphotoxin β receptor signaling via NF-κB.Annals of surgery · 2011Article
- Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patients.Digestive diseases and sciences · 2010Article
- Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity.Langenbeck's archives of surgery · 2009Review
- Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration.Annals of surgery · 2008Article
- Parenteral feeding depletes pulmonary lymphocyte populations.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the effects of parenteral nutrition (PN) on LTbetaR in gut-associated lymphoid tissue (GALT), particularly the intestine and Peyer's patches (PP). SUMMARY BACKGROUND DATA: Lack of enteral stimulation with PN impairs mucosal immunity and reduces IgA levels through depression of GALT cytokines (IL-4 and IL-10) and GALT specific adhesion molecules. We have shown that each is critical to intact mucosal immunity through effects on lymphocyte homing, IgA production, and resistance to antibacterial and antiviral immunity. IgA is the principal specific immunologic mucosal defense. LTbetaR stimulation controls production of IL-4, the adhesion molecule MAdCAM-1, and other key components of GALT, all of which are important in increasing IgA levels and maintaining mucosal defenses.
methodsExperiment 1: LTbetaR expression in intestine and PP was analyzed by Western blot after 5 days of chow, a complex enteral diet (CED), or PN. Diets were isocaloric and isonitrogenous except for chow. Experiment 2: After completing pilot experiments to determine the appropriate dose of the LTbetaR agonistic antibody, mice received chow, PN + 5 mug of anti-LTbetaR mAb (2 times/d, i.v.) or PN + isotype control antibody. PP lymphocytes and intestinal IgA levels were measured after 2 days.
resultsLack of enteral stimulation with PN significantly decreased LTbetaR expression in intestine and PP compared with chow and CED. LTbetaR stimulation with an agonistic anti-LTbetaR mAb significantly increased PP lymphocyte counts and intestinal IgA in PN fed-mice.
conclusionsLTbetaR expression is critical for GALT control mechanisms and intact mucosal immunity. PN reduces LTbetaR expression, PP lymphocytes, and intestinal IgA production. Exogenous LTbetaR stimulation reverses PN-induced depression of gut mucosal immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.