Evidence map›Paper›PMID 16926437›Full record

ArticleInfection and immunity2006

Nucleotide sequence analysis of the enteropathogenic Escherichia coli adherence factor plasmid pMAR7.

Carl Brinkley, Valerie Burland, Rogéria Keller, Debra J Rose, Adam T Boutin, Sara A Klink, Frederick R Blattner, James B Kaper

Abstract read
In one paragraph

Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Whole genome sequencing analysis of enteropathogenicJournal of veterinary science · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Novel Hybrid of Typical EnteropathogenicFrontiers in microbiology · 2018
    Article
  10. Article
  11. Article
  12. Article
  13. Self-Conjugation of the EnteropathogenicBioMed research international · 2017
    Article
  14. Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carl BrinkleyDepartment of Microbiology and Immunology, Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Valerie Burland
Rogéria Keller
Debra J Rose
Adam T Boutin
Sara A Klink
Frederick R Blattner
James B Kaper

Funding

Molecular Genetics of Enteropathogenic E. Coli AdhesionR37AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 2004 to 2013
$4.8M
BACTERIAL PATHOGEN GENOME INITIATIVEU01AI044387 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI BLATTNER, FREDERICK R · 2000 to 2001
$4.4M
MOLECULAR GENETICS OF ENTEROPATHOGENIC E COLI ADHESIONR01AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1989 to 2003
$1.4M
BACTERIAL PATHOGEN GENOME INITIATIVER01AI044387 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI BLATTNER, FREDERICK R · 1998 to 1999
–
MOLECULAR GENETICS OF ENTEROPATHOGENIC E. COLI ADHESIONR22AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1986 to 1991
–
NIAID NIH HHS AI 21657NIAID NIH HHS AI 44387NIAID NIH HHS R01 AI021657NIAID NIH HHS R37 AI021657
6 · The paper itself

Abstract

The complete nucleotide sequence was determined for pMAR7, an enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid that contains genes encoding a type IV attachment pilus (Bfp) and the global virulence regulator per. Prototypic EAF plasmid pMAR7 is self-transmissible, unlike the smaller EAF plasmid pB171, which has no genes encoding conjugative functions. The tra locus, a highly conserved 33-kb segment found in pMAR7, is similar to the tra (conjugation) region of the F plasmid. ISEc13 copies flanking the pMAR7 tra region could potentially mobilize or delete the tra genes. Hybridization of 134 EPEC strains showed that a complete tra region is present only in strains of the EPEC1 clonal group. This study confirms EPEC's potential for dissemination of virulence attributes by horizontal transfer of the EAF plasmid.

Indexed as

Bacterial AdhesionBase SequenceConjugation, GeneticEscherichia coliEscherichia coli ProteinsFimbriae, BacterialFimbriae ProteinsGenes, BacterialMolecular Sequence DataPlasmidsSequence Analysis, DNAEscherichia coli ProteinsFimbriae Proteins

Identifiers

PMID16926437
PMCPMC1594828

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.