ArticleInfection and immunity2006
Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis.Frontiers in immunology · 2025Review
- Implications of a 'Third Signal' in NK Cells.Cells · 2021Review
- Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells DuringFrontiers in microbiology · 2021Article
- Burkholderia pseudomallei ΔmSphere · 2019Article
- Persistence of Burkholderia thailandensis E264 in lung tissue after a single binge alcohol episode.PloS one · 2019Article
- Upregulation of Immune Process-Associated Genes in RAW264.7 Macrophage Cells in Response toBioMed research international · 2018Article
- Article
- Innate immune response to Burkholderia mallei.Current opinion in infectious diseases · 2017Review
- Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei.Scientific reports · 2017Article
- Developmental and Functional Control of Natural Killer Cells by Cytokines.Frontiers in immunology · 2017Review
- The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).Molecular neurobiology · 2014Review
- Oropharyngeal aspiration of Burkholderia mallei and Burkholderia pseudomallei in BALB/c mice.PloS one · 2014Article
- Regulation of mouse NK cell development and function by cytokines.Frontiers in immunology · 2013Review
- Article
- Development of Burkholderia mallei and pseudomallei vaccines.Frontiers in cellular and infection microbiology · 2013Review
- MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.Infection and immunity · 2012Article
- Bystander T cells in human immune responses to dengue antigens.BMC immunology · 2010Article
- A Burkholderia pseudomallei deltapurM mutant is avirulent in immunocompetent and immunodeficient animals: candidate strain for exclusion from select-agent lists.Infection and immunity · 2010Article
- Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Protection from pneumonic infection with burkholderia species by inhalational immunotherapy.Infection and immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Burkholderia mallei is a gram-negative bacterium which causes the potentially fatal disease glanders in humans; however, there is little information concerning cell-mediated immunity to this pathogen. The role of gamma interferon (IFN-gamma) during B. mallei infection was investigated using a disease model in which infected BALB/c mice normally die between 40 and 60 days postinfection. IFN-gamma knockout mice infected with B. mallei died within 2 to 3 days after infection, and there was uncontrolled bacterial replication in several organs, demonstrating the essential role of IFN-gamma in the innate immune response to this pathogen. Increased levels of IFN-gamma, interleukin-6 (IL-6), and monocyte chemoattractant protein 1 were detected in the sera of immunocompetent mice in response to infection, and splenic mRNA expression of IFN-gamma, IL-6, IL-12p35, and IL-27 was elevated 24 h postinfection. The effects of IL-18, IL-27, and IL-12 on stimulation of the rapid IFN-gamma production were investigated in vitro by analyzing IFN-gamma production in the presence of heat-killed B. mallei. IL-12 was essential for IFN-gamma production in vitro; IL-18 was also involved in induction of IFN-gamma, but IL-27 was not required for IFN-gamma production in response to heat-killed B. mallei. The main cellular sources of IFN-gamma were identified in vitro as NK cells, CD8+ T cells, and TCRgammadelta T cells. Our data show that B. mallei is susceptible to cell-mediated immune responses which promote expression of type 1 cytokines. This suggests that development of effective vaccines against glanders should target the production of IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.