ArticleProceedings of the National Academy of Sciences of the United States of America1990
Expression of microtubule-associated protein 2 by reactive astrocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
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- Comparison of two protocols for the generation of iPSC-derived human astrocytes.Biological procedures online · 2023Article
- Single Cerebral Organoid Mass Spectrometry of Cell-Specific Protein and Glycosphingolipid Traits.Analytical chemistry · 2023Article
- Isolation and culture of functional adult human neurons from neurosurgical brain specimens.Brain communications · 2020Article
- Altered expression of itch‑related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch.International journal of molecular medicine · 2019Article
- A single factor induces neuronal differentiation to suppress glioma cell growth.CNS neuroscience & therapeutics · 2019Article
- Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice.Journal of Alzheimer's disease : JAD · 2019Article
- Projection length stimulated by oxytocin is modulated by the inhibition of calcium signaling in U-87MG cells.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.Scientific reports · 2016Article
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- Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue.Brain pathology (Zurich, Switzerland) · 2016Article
- Microtissue engineered constructs with living axons for targeted nervous system reconstruction.Tissue engineering. Part A · 2012Article
- Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism.Journal of virology · 2008Article
- Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.The Journal of biological chemistry · 2008Article
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- NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation.The Journal of cell biology · 1998Article
- Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
After an injury to the central nervous system, a dramatic change in the astrocytes bordering the wound occurs. The most characteristic feature of this process, termed reactive gliosis, is the upregulation of the intermediate filament protein, glial fibrillary acidic protein. In the present study, we show that reactive astrocytes express high levels of microtubule-associated protein 2 (MAP-2), a protein normally found in the somatodendritic compartment of neurons. When sections of injured brain are double-stained with antibodies directed against MAP-2 and glial fibrillary protein, all of the reactive astrocytes are found to contain MAP-2. The high levels of this protein appear to represent a permanent change in reactive astrocytes. In parallel quantitative studies, an elevated level of MAP-2 in the injured brain is confirmed by an immunoblot analysis of injured and normal white matter. This report demonstrates the direct involvement of a microtubule protein in the process of reactive gliosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.