ArticleProceedings of the National Academy of Sciences of the United States of America1990
BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 156 citations in OpenAlex.
- Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.Frontiers in pediatrics · 2016Review
- Targeting BCL2-Proteins for the Treatment of Solid Tumours.Advances in medicine · 2014Review
- Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human Lung Cancer Cells.Scientifica · 2014Review
- Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small molecule.Journal of hematopathology · 2009Article
- Review
- The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA.Cellular & molecular biology letters · 2008Article
- Mitochondriotoxic compounds for cancer therapy.Oncogene · 2006Review
- Cellular and molecular themes in apoptosis.Wiener klinische Wochenschrift · 2003Review
- Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.Leukemia · 2003Review
- Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Molecular and cellular biology · 2001Article
- Role of the Bcl-2 gene family in prostate cancer progression and its implications for therapeutic intervention.Environmental health perspectives · 1999Review
- Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Expression of galectin-3 modulates T-cell growth and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Effect of Wnt-1 antisense RNA on the outgrowth of a mammary adenocarcinoma cell line expressing that oncogene.Clinical molecular pathology · 1996Article
- A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Design and application of antisense oligonucleotides in cell culture, in vivo, and as therapeutic agents.Cellular and molecular neurobiology · 1994Review
- The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis.Annals of hematology · 1994Article
- Bcl-2 expression in normal endometrium during the menstrual cycle.The American journal of pathology · 1994Article
- Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation.The Biochemical journal · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A gene-transfer approach was used to explore the function of the BCL2 (B-cell lymphoma/leukemia 2) gene in a human T-cell line, Jurkat. Though stable introduction of a BCL2 expression plasmid into Jurkat T cells was by itself insufficient, the combined transfer of BCL2 and MYC genes markedly enhanced the tumorigenicity of these cells in athymic mice. Moreover, a BCL2 antisense expression plasmid ablated tumor formation by Jurkat cells, providing further evidence that this oncogene contributes to the regulation of the in vivo growth of these human T lymphocytes. In addition to their influence on tumor formation, BCL2 sense and antisense expression plasmids increased and decreased, respectively, the in vitro survival of Jurkat T cells in serum-free medium. These observations extend to T cells the finding of synergy of BCL2 with MYC previously reported for B cells and provide evidence that BCL2 can regulate the growth of human T cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.