Trial reportEuropean journal of applied physiology2006
Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives.
Trial report in European journal of applied physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Isometric hand grip training on populations with different baseline resting blood pressure: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Can resistance training alone or resistance training combined with aerobic training improve arterial stiffness, endothelial function, and other vascular function indicators in adults with hypertension or overweight/obesity-related vascular risk? A systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Effects of Different Types of Exercise Training on Endothelial Function in Prehypertensive and Hypertensive Individuals: A Systematic Review.Arquivos brasileiros de cardiologia · 2021Pooled it
- Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women.European journal of applied physiology · 2010Trial
- Isometric Handgrip Training and Cardiovascular Risk Modulation: State of the Art.Journal of cardiovascular development and disease · 2026Review
- Article
- Association between handgrip strength and hypertension in children and adolescents: an analysis of the National Health and Nutrition Examination Survey 2011-2014.Frontiers in pediatrics · 2025Article
- Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.American journal of physiology. Heart and circulatory physiology · 2021Article
- Exercise Training and Endothelial Function in Hypertension: Effects of Aerobic and Resistance Training.Arquivos brasileiros de cardiologia · 2021Article
- Resistance exercise with different volumes: blood pressure response and forearm blood flow in the hypertensive elderly.Clinical interventions in aging · 2014Article
- Double-leg isometric exercise training in older men.Open access journal of sports medicine · 2013Article
- Blood flow restricted exercise and vascular function.International journal of vascular medicine · 2012Article
- Effects of the intensity of leg isometric training on the vasculature of trained and untrained limbs and resting blood pressure in middle-aged men.International journal of vascular medicine · 2012Article
- The association of arterial shear and flow-mediated dilation in diabetes.Vascular medicine (London, England) · 2011Article
- Current evidence on the hemodynamic and blood pressure effects of isometric exercise in normotensive and hypertensive persons.Journal of clinical hypertension (Greenwich, Conn.) · 2010Review
- Impact of inactivity and exercise on the vasculature in humans.European journal of applied physiology · 2010Review
- The effects of performing isometric training at two exercise intensities in healthy young males.European journal of applied physiology · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bilateral isometric handgrip (IHG) training lowers resting arterial blood pressure (BP) in medicated hypertensives. Numerous mechanisms have been suggested, but have yet to be investigated. One such mechanism is that of improved systemic endothelial-dependent vasodilation. The purpose of this investigation was twofold: (1) to determine if Bilateral IHG training had any beneficial effects on endothelial-dependent vasodilation, and (2) to see if improved systemic endothelial-dependent vasodilation was responsible for lowering BP. Sixteen participants performed four, 2 min IHG contractions at 30% of their maximal voluntary effort, using either a Bilateral (n = 7) or a Unilateral IHG protocol (n = 9), three times per week for 8 weeks. Brachial artery (BA) flow-mediated dilation (FMD, an index of endothelial-dependent vasodilation, measured in both arms) was assessed pre-and post-training. Following Bilateral IHG training, BA FMD improved in both arms (normalized to peak shear rate, 0.005 +/- 0.001 to 0.02 +/- 0.002 s(-1), P < 0.01). Following Unilateral IHG training, BA FMD improved in the trained arm only (normalized: 0.009 +/- 0.002 to 0.02 +/- 0.005 s(-1), P < 0.01). These findings suggest that although IHG training improves endothelial-dependent vasodilation, the improvements occur only locally in the trained limbs. This suggests that enhanced systemic endothelial-dependent vasodilation is not the mechanism responsible for the observed post-IHG training reductions in BP in medicated hypertensives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.