ArticleVirchows Archiv. A, Pathological anatomy and histopathology1990
Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Feasibility of intraoperative indocyanine green injection to identify lymph nodes at risk of metastatic disease for early-stage lung cancer.JTCVS techniques · 2025Article
- Cytokeratin expression and distribution pattern of epithelioid macrophages in animals with different pathological forms of bovine paratuberculosis: potential role in resilience to PTB.Frontiers in veterinary science · 2025Article
- Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type.Diagnostic pathology · 2020Article
- Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer.Diagnostic pathology · 2016Article
- Article
- The clinical significance of lymph node micrometastasis in stage I and stage II colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2008Article
- Pathologic examination of the axillary sentinel lymph nodes in patients with early-stage breast carcinoma: current and resolving controversies on the basis of the European Institute of Oncology experience.Virchows Archiv : an international journal of pathology · 2006Review
- Clinical significance of occult micrometastases in axillary lymph nodes in "node-negative" breast cancer patients.Japanese journal of cancer research : Gann · 2002Article
- The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?The American journal of pathology · 2001Article
- Increased numbers of cytokeratin-positive interstitial reticulum cells (CIRC) in reactive, inflammatory and neoplastic lymphadenopathies: hyperplasia or induced expression?Virchows Archiv : an international journal of pathology · 1995Article
- Common acute lymphoblastic leukaemia-lymphoma expressing cytokeratin: a case report.Virchows Archiv : an international journal of pathology · 1994Article
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Authors and funding
6 authors.
Funding
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Abstract
The occurrence and the distribution of cytokeratin (CK)-immunoreactive reticulum cells in a series of normal and pathological human lymph nodes and spleens are documented. The immunoreactive cells exhibit morphological and immunophenotypic features of so-called fibroblastic reticulum cells, with or without myoid differentiation. They invariably co-express vimentin and, to a lesser extent, desmin and muscle-specific actin isoforms. These CK-immunoreactive cells are apparently a normal subpopulation of reticulum cells, being detectable from the early stages of spleen and lymph node development. They are distributed mainly in the paracortical and medullary regions of the lymph nodes and at the periphery of the white pulp in the spleen. Their number and distribution are highly variable in different neoplastic and non-neoplastic pathological conditions but the changes are not disease specific. CK-immunoreactive reticulum cells are easily identifiable in both frozen and fixed lymphoid tissue and in cytological smears of fine-needle aspirates, provided that monoclonal antibodies whose spectrum of reactivity includes cytokeratins 8 and 18 are used. The awareness of the occurrence of CK-immunoreactive cells in normal lymphoid tissues is of particular relevance in the search for micrometastatic foci using anti-CK antibodies.
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