ArticleOncogene2007
Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
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- Restorative Mechanism of Neural Progenitor Cells Overexpressing Arginine Decarboxylase Genes Following Ischemic Injury.Experimental neurobiology · 2019Article
- Protective role of integrin-linked kinase against oxidative stress and in maintenance of genomic integrity.Oncotarget · 2018Article
- A reporter mouse model forBiology open · 2017Article
- CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.Oncotarget · 2017Article
- Article
- Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.Journal of neurochemistry · 2014Article
- Looking beyond the Wnt pathway for the deep nature of β-catenin.EMBO reports · 2013Review
- Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer.Molecular & cellular proteomics : MCP · 2012Article
- Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.Medical microbiology and immunology · 2012Article
- 75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes.Arthritis and rheumatism · 2012Article
- Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling.PloS one · 2012Article
- Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation.BMC genomics · 2010Article
- E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage.Neuroscience letters · 2010Article
- hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization.Nucleic acids research · 2010Article
- Integrin-linked kinase interactions with ELMO2 modulate cell polarity.Molecular biology of the cell · 2009Article
- Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation.Oncogene · 2009Article
- Location, location, location: altered transcription factor trafficking in neurodegeneration.Journal of neuropathology and experimental neurology · 2007Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E2F factors modulate a plethora of cell functions, including proliferation, differentiation, DNA repair and apoptosis. We have shown that differentiation in primary epidermal keratinocytes leads to E2F1 downregulation via activation of protein kinase C and p38 mitogen-activated protein kinase. We now demonstrate that E2F1 downregulation in differentiating keratinocytes involves its ubiquitination, as well as proteasomal degradation subsequent to CRM1-dependent nuclear export. E2F1 nuclear export specifically in response to differentiation requires regions adjacent to the cyclin A-binding domain in the N-terminus of this protein. Significantly, inhibition of p38 interferes with nuclear export and degradation of E2F1 during differentiation, but has no effect on E2F1 in undifferentiated cells. Thus, induction of differentiation in epidermal keratinocytes activates a specific program for post-transcriptional downregulation of E2F1, which involves signaling through p38 and activation of nuclear export pathways.
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