ArticleMolecular and cellular biology2006
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Characterization of a New Hsp110 Inhibitor as a Potential Antifungal.Journal of fungi (Basel, Switzerland) · 2024Article
- Protein disulfide isomerase is essential for spermatogenesis in mice.JCI insight · 2024Article
- Review
- HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption.PloS one · 2024Article
- A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi.Nature communications · 2023Article
- Expression ofInternational journal of molecular sciences · 2022Article
- Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.Cell reports · 2022Article
- Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation.BMC genomic data · 2022Article
- Comparison of miRNA and mRNA Expression in Sika Deer Testes With Age.Frontiers in veterinary science · 2022Article
- Developmental pathology of congenital kidney and urinary tract anomalies.Clinical kidney journal · 2019Article
- Identification and profiling of microRNAs during gonadal development in the giant freshwater prawn Macrobrachium rosenbergii.Scientific reports · 2019Article
- Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations.American journal of human genetics · 2017Article
- Potential contributions of heat shock proteins and related genes in sexual differentiation in yellow catfish (Pelteobagrus fulvidraco).Fish physiology and biochemistry · 2017Article
- Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity.Scientific reports · 2016Article
- Impact of precise modulation of reactive oxygen species levels on spermatozoa proteins in infertile men.Clinical proteomics · 2015Article
- Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.PloS one · 2015Article
- Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease.Inflammatory bowel diseases · 2015Article
- TAp73 is essential for germ cell adhesion and maturation in testis.The Journal of cell biology · 2014Article
- Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging.Pathobiology of aging & age related diseases · 2014Article
- Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.Molecular & cellular proteomics : MCP · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hspa4l gene, also known as Apg1 or Osp94, belongs to the HSP110 heat shock gene family, which includes three genes encoding highly conserved proteins. This study shows that Hspa4l is expressed ubiquitously and predominantly in the testis. The protein is highly expressed in spermatogenic cells, from late pachytene spermatocytes to postmeiotic spermatids. In the kidney, the protein is restricted to cortical segments of distal tubules. To study the physiological role of this gene in vivo, we generated mice deficient in Hspa4l by gene targeting. Hspa4l-deficient mice were born at expected ratios and appeared healthy. However, approximately 42% of Hspa4l(-/-) male mice suffered from fertility defects. Whereas the seminiferous tubules of Hspa4l(-/-) testes contained all stages of germ cells, the number of mature sperm in the epididymis and sperm motility were drastically reduced. The reduction of the sperm count was due to the elimination of a significant number of developing germ cells via apoptosis. No defects in fertility were observed in female mutants. In addition, 12% of null mutant mice developed hydronephrosis. Concentrations of plasma and urine electrolytes in Hspa4l(-/-) mice were similar to wild-type values, suggesting that the renal function was not impaired. However, Hspa4l(-/-) animals were preferentially susceptible to osmotic stress. These results provide evidence that Hspa4l is required for normal spermatogenesis and suggest that Hspa4l plays a role in osmotolerance.
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