ArticleJournal of bacteriology2006
Antimutator role of the DNA glycosylase mutY gene in Helicobacter pylori.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- ThemBio · 2025Article
- Antibiotic-induced ROS-mediated Fur allosterism contributes toAntimicrobial agents and chemotherapy · 2024Article
- Assessment of microbiota in the gut and upper respiratory tract associated with SARS-CoV-2 infection.Microbiome · 2023Article
- Article
- Mutators Enhance Adaptive Micro-Evolution in Pathogenic Microbes.Microorganisms · 2022Review
- Structural and Functional Characterization of a Unique AP Endonuclease FromFrontiers in microbiology · 2020Article
- The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori.Nucleic acids research · 2019Article
- Identification of aFrontiers in microbiology · 2019Article
- Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori.PloS one · 2018Article
- Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination.DNA repair · 2017Article
- ComB proteins expression levels determine Helicobacter pylori competence capacity.Scientific reports · 2017Article
- Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.FEMS microbiology reviews · 2016Article
- A single nucleotide change in mutY increases the emergence of antibiotic-resistant Campylobacter jejuni mutants.The Journal of antimicrobial chemotherapy · 2015Article
- Positive selection is the main driving force for evolution of citrus canker-causing Xanthomonas.The ISME journal · 2015Article
- Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes.Nature communications · 2015Article
- The BER necessities: the repair of DNA damage in human-adapted bacterial pathogens.Nature reviews. Microbiology · 2015Review
- Role of DNA base excision repair in the mutability and virulence of Streptococcus mutans.Molecular microbiology · 2012Article
- The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation.BMC microbiology · 2012Article
- Phylogenomic analysis of the uracil-DNA glycosylase superfamily.Molecular biology and evolution · 2011Article
- Coadaptation of Helicobacter pylori and humans: ancient history, modern implications.The Journal of clinical investigation · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter pylori has a highly variable genome with ongoing diversification via inter- and intragenomic recombination and spontaneous mutation. DNA repair genes modulating mutation and recombination rates that influence diversification have not been well characterized for H. pylori. To examine the role of putative base excision repair ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, mutants of each were constructed in strain JP26 by allelic exchange. Spontaneous mutation frequencies of JP26 mutY mutants, assessed by rifampin resistance, were consistently higher (26-fold) than that of the wild type, whereas the ung and xthA mutants showed smaller increases. In trans complementation of the JP26 mutY mutant restored spontaneous mutation frequencies to wild-type levels. In cross-species studies, H. pylori mutY complemented an Escherichia coli mutY mutant and vice versa. In contrast, the ung and mutY mutants did not show higher frequencies of intergenomic recombination or greater sensitivity to UV-induced DNA damage than the wild type. The H. pylori mutY open reading frame contains an eight-adenine homonucleotide tract; we provide evidence that this is subject to slipped-strand mispairing, leading to frameshifts that eliminate gene function. Our findings indicate that H. pylori possesses phase-variable base excision repair, consistent with a tension between repair and mutation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.