ArticleJournal of bacteriology2006
Cluster of DnaA boxes involved in regulation of Streptomyces chromosome replication: from in silico to in vivo studies.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Evidence supporting the first secondary chromosome in Actinobacteria as a hallmark of theMicrobial genomics · 2026Article
- Read-through transcription of tRNA underlies the cell cycle-dependent dissociation of IHF from the DnaA-inactivating sequenceFrontiers in microbiology · 2024Article
- Streptomyces sp. M54: an actinobacteria associated with a neotropical social wasp with high potential for antibiotic production.Antonie van Leeuwenhoek · 2021Article
- Control of bacterial chromosome replication by non-coding regions outside the origin.Current genetics · 2017Review
- New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18.Scientific reports · 2017Article
- Cooperative DnaA Binding to the Negatively Supercoiled datA Locus Stimulates DnaA-ATP Hydrolysis.The Journal of biological chemistry · 2017Article
- The DnaA Cycle inFrontiers in microbiology · 2017Review
- Control regions for chromosome replication are conserved with respect to sequence and location among Escherichia coli strains.Frontiers in microbiology · 2015Article
- Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.BMC genomics · 2014Article
- Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.Journal of bacteriology · 2014Review
- Regulating DNA replication in bacteria.Cold Spring Harbor perspectives in biology · 2013Review
- DnaA binding locus datA promotes DnaA-ATP hydrolysis to enable cell cycle-coordinated replication initiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Helicobacter pylori oriC--the first bipartite origin of chromosome replication in Gram-negative bacteria.Nucleic acids research · 2012Article
- Regulation of chromosomal replication initiation by oriC-proximal DnaA-box clusters in Bacillus subtilis.Nucleic acids research · 2012Article
- Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum.Microbiology and molecular biology reviews : MMBR · 2007Review
- Distribution of stable DnaA-binding sites on the Bacillus subtilis genome detected using a modified ChIP-chip method.DNA research : an international journal for rapid publication of reports on genes and genomes · 2007Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Streptomyces coelicolor, replication is initiated by the DnaA protein in the centrally located oriC region and proceeds bidirectionally until the replication forks reach the ends of the linear chromosome. We identified three clusters of DnaA boxes (H69, H24, and D78) which are in a relatively short segment of the chromosome centered on the oriC region. Of the clusters analyzed, D78 exhibited the highest affinity for the DnaA protein; the affinity of DnaA for the D78 cluster was about eightfold higher than the affinity for oriC. The high-affinity DnaA boxes appear to be involved in the control of chromosome replication. Deletion of D78 resulted in more frequent chromosome replication (an elevated ratio of origins to chromosome ends was observed) and activated aerial mycelium formation, leading to earlier colony maturation. In contrast, extra copies of D78 (delivered on a plasmid) caused slow colony growth, presumably because of a reduction in the frequency of initiation of chromosome replication. This suggests that the number of high-affinity DnaA boxes is relatively constant in hyphal compartments and that deletion of D78 therefore permits an increased copy number of either the chromosomal origin region or a plasmid harboring the D78 cluster. This system conceivably influences the timing of decisions to initiate aerial mycelial formation and sporulation.
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