ArticleJournal of bacteriology2006
Genome sequence and global gene expression of Q54, a new phage species linking the 936 and c2 phage species of Lactococcus lactis.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Cryo-EM structure of bacteriophage Nocturne116: insights into the architecture of c2-likeJournal of virology · 2026Article
- Revisiting lactococcal abortive infection-like antiphage systems: diversity, structures, and mechanisms.FEMS microbiology reviews · 2026Review
- Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system inmSphere · 2023Article
- Isolation and characterization of two homolog phages infectingFrontiers in microbiology · 2022Article
- Article
- Genome Characterization of Nocturne116, NovelMicroorganisms · 2021Article
- Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria.Nature communications · 2020Review
- Complete Genome Sequences of 28 Lactococcal Bacteriophages Isolated from Failed Dairy Fermentation Processes.Microbiology resource announcements · 2020Article
- A Specific Sugar Moiety in the Lactococcus lactis Cell Wall Pellicle Is Required for Infection by CHPC971, a Member of the Rare 1706 Phage Species.Applied and environmental microbiology · 2019Article
- Article
- Two novel temperate bacteriophages infecting Streptococcus pyogenes: Their genomes, morphology and stability.PloS one · 2018Article
- Phage Biodiversity in Artisanal Cheese Wheys Reflects the Complexity of the Fermentation Process.Viruses · 2017Article
- Global Survey and Genome Exploration of Bacteriophages Infecting the Lactic Acid BacteriumFrontiers in microbiology · 2017Article
- Identification and Analysis of a Novel Group of Bacteriophages Infecting the Lactic Acid Bacterium Streptococcus thermophilus.Applied and environmental microbiology · 2016Article
- Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages.Scientific reports · 2016Article
- Structural proteins ofBacteriophage · 2016Article
- A virulent phage infecting Lactococcus garvieae, with homology to Lactococcus lactis phages.Applied and environmental microbiology · 2015Article
- Molecular characterization of three Lactobacillus delbrueckii subsp. bulgaricus phages.Applied and environmental microbiology · 2014Article
- Progress in lactic acid bacterial phage research.Microbial cell factories · 2014Review
- Phages of non-dairy lactococci: isolation and characterization of ΦL47, a phage infecting the grass isolate Lactococcus lactis ssp. cremoris DPC6860.Frontiers in microbiology · 2014Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lytic lactococcal phage Q54 was previously isolated from a failed sour cream production. Its complete genomic sequence (26,537 bp) is reported here, and the analysis indicated that it represents a new Lactococcus lactis phage species. A striking feature of phage Q54 is the low level of similarity of its proteome (47 open reading frames) with proteins in databases. A global gene expression study confirmed the presence of two early gene modules in Q54. The unusual configuration of these modules, combined with results of comparative analysis with other lactococcal phage genomes, suggests that one of these modules was acquired through recombination events between c2- and 936-like phages. Proteolytic cleavage and cross-linking of the major capsid protein were demonstrated through structural protein analyses. A programmed translational frameshift between the major tail protein (MTP) and the receptor-binding protein (RBP) was also discovered. A "shifty stop" signal followed by putative secondary structures is likely involved in frameshifting. To our knowledge, this is only the second report of translational frameshifting (+1) in double-stranded DNA bacteriophages and the first case of translational coupling between an MTP and an RBP. Thus, phage Q54 represents a fascinating member of a new species with unusual characteristics that brings new insights into lactococcal phage evolution.
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