ArticleInfection and immunity2006
Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
107 citing papers in PubMed, 267 citations in OpenAlex.
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- Effects of dietary benzoic acid combined with cinnamon essential oil on growth performance, antioxidant capacity, immune function, and gut health in broiler, chickens with necrotic enteritis.Poultry science · 2026Article
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- Toxinotyping, Antibiotic Resistance Profile, and In Vitro Bio-Control ofAntibiotics (Basel, Switzerland) · 2026Article
- Development of a Clostridium Perfringens Challenge Model in Broiler Chickens to Evaluate the Effects of Feed Additives.Pathogens (Basel, Switzerland) · 2025Article
- Comprehensive analysis of blood proteome response to necrotic enteritis in broiler chicken.Veterinary research · 2025Article
- Blood proteome profiling for biomarker discovery in broilers with necrotic enteritis.Scientific reports · 2025Article
- The Mechanistic Target of Rapamycin MediatesMicroorganisms · 2025Article
- First genomic analysis of aFrontiers in microbiology · 2025Article
- Genomic Diversity and Virulence Factors ofMicroorganisms · 2024Article
- Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens.PLoS pathogens · 2024Article
- Preparation and Application ofVeterinary sciences · 2024Article
- Necrotic enteritis and antibiotic-free production of broiler chickens: Challenges in testing and using alternative products.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Exploring the predictive power of jejunal microbiome composition in clinical and subclinical necrotic enteritis caused by Clostridium perfringens: insights from a broiler chicken model.Journal of translational medicine · 2024Article
- The effect of butyric acid and nucleotides supplementation on broiler (Open veterinary journal · 2024Article
- A comprehensive review of experimental models and induction protocols for avian necrotic enteritis over the past 2 decades.Frontiers in veterinary science · 2024Review
- Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.EMBO reports · 2023Article
- Animal Model Studies, Antibiotic Resistance and Toxin Gene Profile of NE ReproducingMicroorganisms · 2023Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.