ArticleInfection and immunity2006
Discordance in the effects of Yersinia pestis on the dendritic cell functions manifested by induction of maturation and paralysis of migration.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Transcriptomic Assessment of Host Responses in Vaccinia and Venezuelan Equine Encephalitis Virus-Infected Human Dendritic Cells.Biomolecules · 2026Article
- Mechanical Forces Govern Interactions of Host Cells with Intracellular Bacterial Pathogens.Microbiology and molecular biology reviews : MMBR · 2022Review
- Migration of dendritic cells facilitates systemic dissemination of Burkholderia pseudomallei.Infection and immunity · 2014Article
- Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network.Infection and immunity · 2011Article
- Tn5AraOut mutagenesis for the identification of Yersinia pestis genes involved in resistance towards cationic antimicrobial peptides.Microbial pathogenesis · 2011Article
- Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic mice.Infection and immunity · 2010Article
- Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague.Infection and immunity · 2009Article
- Article
- Activation of ERK-FAK signaling pathway and enhancement of cell migration involved in the early interaction between oral keratinocytes and Candida albicans.Mycopathologia · 2009Article
- Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection.PLoS pathogens · 2008Article
- Immune defense against pneumonic plague.Immunological reviews · 2008Review
- Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.PLoS pathogens · 2008Article
- Interaction between Yersinia pestis and the host immune system.Infection and immunity · 2008Review
- Haemophilus ducreyi partially activates human myeloid dendritic cells.Infection and immunity · 2007Article
- The fraction 1 and V protein antigens of Yersinia pestis activate dendritic cells to induce primary T cell responses.Clinical and experimental immunology · 2007Article
- Respiratory dendritic cells: mediators of tolerance and immunity.Immunologic research · 2007Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The encounter between invading microorganisms and dendritic cells (DC) triggers a series of events which include uptake and degradation of the microorganism, induction of a maturation process, and enhancement of DC migration to the draining lymph nodes. Various pathogens have developed strategies to counteract these events as a measure to evade the host defense. In the present study we found that interaction of the Yersinia pestis EV76 strain with DC has no effect on cell viability and is characterized by compliance with effective maturation, which is manifested by surface display of major histocompatibility complex class II, of costimulatory markers, and of the chemokine receptor CCR7. This is in contrast to maturation inhibition and cell death induction exerted by the related species Yersinia enterocolitica WA O:8. Y. pestis interactions with DC were found, however, to impair functions related to cytoskeleton rearrangement. DC pulsed with Y. pestis failed to adhere to solid surfaces and to migrate toward the chemokine CCL19 in an in vitro transmembrane assay. Both effects were dependent on the presence of the pCD1 virulence plasmid and on a bacterial growth shift to 37 degrees C prior to infection. Moreover, while instillation of a pCD1-cured Y. pestis strain into mouse airways triggered effective transport of alveolar DC to the mediastinal lymph node, instillation of Y. pestis harboring the plasmid failed to do so. Taken together, these results suggest that virulence plasmid-dependent impairment of DC migration is the major mechanism utilized by Y. pestis to subvert DC function.
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