ArticleCell2006
Matrix control of stem cell fate.
Article in Cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed.
- Biomimetic mineralization of electrospun elastin-like recombinamer nanofibers.Scientific reports · 2026Article
- From Bench to Bedside: Translational Barriers in Mesenchymal Stem Cell Therapy for Intervertebral Disc Degeneration.Bioengineering (Basel, Switzerland) · 2026Review
- Interrogating functional connectivity of in vitro neural glia tissue model modulated through integrative control of matrix stiffness and a neurotrophic factor.Biomaterials · 2026Article
- Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation.Nature communications · 2026Article
- Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration.Bioactive materials · 2025Article
- A designer minimalistic model parallels the phase-separation-mediated assembly and biophysical cues of extracellular matrix.Nature chemistry · 2025Article
- Tissue-engineered liver using 3D-printed silk fibroin scaffolds loaded with stem cells for the treatment of acute liver injury.Regenerative biomaterials · 2025Article
- Design and evaluation of ionically crosslinked multifunctional ELP-SA composite hydrogels for 3D cell culture.Regenerative biomaterials · 2025Article
- Hydrogels with reversible stiffness modulation: new materials for studying dynamic mechanical cues that regulate cell behavior.Frontiers in bioengineering and biotechnology · 2025Review
- Photo-Clickable Triazine-Trione Thermosets as Promising 3D Scaffolds for Tissue Engineering Applications.Advanced healthcare materials · 2024Article
- The Effect of Crosslinking Density on Nasal Chondrocytes' Redifferentiation.Annals of biomedical engineering · 2024Article
- The Role of Biophysical Factors in Organ Development: Insights from Current Organoid Models.Bioengineering (Basel, Switzerland) · 2024Review
- The Plasma Membrane and Mechanoregulation in Cells.ACS omega · 2024Review
- Optical redox imaging to screen synthetic hydrogels for stem cell-derived cardiomyocyte differentiation and maturation.Biophotonics discovery · 2024Article
- Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes.Basic research in cardiology · 2024Article
- Stretching of porous poly (l-lactide-co-ε-caprolactone) membranes regulates the differentiation of mesenchymal stem cells.Frontiers in cell and developmental biology · 2024Article
- Engineering the viscoelasticity of gelatin methacryloyl (GelMA) hydrogels via small "dynamic bridges" to regulate BMSC behaviors for osteochondral regeneration.Bioactive materials · 2023Article
- Modulation of stem cell fate in intestinal homeostasis, injury and repair.World journal of stem cells · 2023Review
- Hydrogels from TEMPO-Oxidized Nanofibrillated Cellulose SupportACS applied bio materials · 2023Article
- Hydrogel-based microenvironment engineering of haematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2023Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
Abstract
A key challenge in stem cell research is to learn how to direct the differentiation of stem cells toward specific fates. In this issue of Cell, Engler et al. (2006) identify a new factor regulating stem cell fate: the elasticity of the matrix microenvironment. By changing the stiffness of the substrate, human mesenchymal stem cells could be directed along neuronal, muscle, or bone lineages.
Indexed as
Identifiers
16923382What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.