ArticleRespiratory research2006
Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones.
Article in Respiratory research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Insights from precision-cut lung slices-investigating mechanisms and therapeutics for pulmonary hypertension.Respiratory research · 2025Review
- Perspectives on precision cut lung slices-powerful tools for investigation of mechanisms and therapeutic targets in lung diseases.Frontiers in pharmacology · 2023Review
- Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery.American journal of respiratory cell and molecular biology · 2020Review
- Preventing bronchopulmonary dysplasia: new tools for an old challenge.Pediatric research · 2019Review
- Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Review
- Vitamin C acts as a hepatoprotectant in carbofuran treated rat liver slicesToxicology reports · 2017Article
- Integrative understanding of hypoxic pulmonary vasoconstriction usingIntegrative medicine research · 2014Review
- Adrenomedullin and adrenotensin regulate collagen synthesis and proliferation in pulmonary arterial smooth muscle cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Assessment of immunotoxicity using precision-cut tissue slices.Xenobiotica; the fate of foreign compounds in biological systems · 2013Review
- Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.Experimental cell research · 2012Article
- Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation.The Journal of physiology · 2012Article
- Requirement of Pretone by Thromboxane A(2) for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- Exploring lung physiology in health and disease with lung slices.Pulmonary pharmacology & therapeutics · 2011Review
- Direct leukocyte migration across pulmonary arterioles and venules into the perivascular interstitium of murine lungs during bleomycin injury and repair.The American journal of pathology · 2011Article
- Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.Nature protocols · 2010Article
- Circadian timing in the lung; a specific role for bronchiolar epithelial cells.Endocrinology · 2009Article
- COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contracted airways, but had no vascular effect. The thromboxane mimetic, U46619 contracted both vessels and airways. In the presence of U46619, acetylcholine dilated vessels, but further contracted airways, an effect that was blocked by the nitric oxide synthase inhibitor L-NG-nitro-L-arginine or apamin plus charybdotoxin, which inhibit endothelial-derived hyperpolarising factor. Airway responses in lung slices were unaffected by L-NGnitro-L-arginine methyl ester, indomethacin or apamin plus charybdotoxin. By contrast, apamin plus charybdotoxin contracted bronchi studied in isolation. Our observations are the first to identify mechanisms of endothelium dependent dilations in precision cut lung slices and the potential for transverse hormonal communication between airways and vessels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.