Evidence map›Paper›PMID 16921475›Full record

ReviewMass spectrometry reviews

Mass spectrometry-based metabolomics.

Katja Dettmer, Pavel A Aronov, Bruce D Hammock

Abstract readReview
In one paragraph

Review in Mass spectrometry reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 675 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
675citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

675 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Metabolomics analyses and physical interventions in soccer: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2024
    Pooled it
  3. Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
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615 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katja DettmerDepartment of Entomology, University of California at Davis, Davis, California 95616, USA.
Pavel A Aronov
Bruce D Hammock

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
NIEHS Center for Health Effects of AgrochemicalsP30ES005707 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI MATSUMURA, FUMIO NONE · 1992 to 2006
$9.9M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR37ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1998 to 2007
$3.0M
Metabolomic study of ozone and nitronaphthalene toxicityR01ES013933 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 2005 to 2009
$1.5M
NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P01 ES11269NIEHS NIH HHS P30 ES005707NIEHS NIH HHS P30 ES05707NIEHS NIH HHS P42 ES004699NIEHS NIH HHS P42 ES04699NIEHS NIH HHS R01 ES013933NIEHS NIH HHS R37 ES002710
6 · The paper itself

Abstract

This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. These numerous analytes have very diverse physico-chemical properties and occur at different abundance levels. Consequently, comprehensive metabolomics investigations are primarily a challenge for analytical chemistry and specifically mass spectrometry has vast potential as a tool for this type of investigation. Metabolomics require special approaches for sample preparation, separation, and mass spectrometric analysis. Current examples of those approaches are described in this review. It primarily focuses on metabolic fingerprinting, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes. To perform this complex task, data analysis tools, metabolite libraries, and databases are required. Therefore, recent advances in metabolomics bioinformatics are also discussed.

Indexed as

Databases, ProteinGene Expression ProfilingInformation Storage and RetrievalMass SpectrometryPeptide MappingProteomeProteome

Identifiers

PMID16921475
PMCPMC1904337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.