ArticleThe Plant cell2006
Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 204 citations in OpenAlex.
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- From herbarium to life: Implications of reviving historical fungi for modern plant pathology and agriculture.iScience · 2025Article
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- Seeing the unseen in characterizing RNA editome during rice endosperm development.Communications biology · 2024Article
- The host and pathogen myo-inositol-1-phosphate synthases are required for Rhizoctonia solani AG1-IA infection in tomato.Molecular plant pathology · 2024Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Genome-Wide Characterization of Soybean Hexokinase Genes Reveals a Positive Role ofPlants (Basel, Switzerland) · 2023Article
- Identification and Characterization of VDAC Family in Maize.Plants (Basel, Switzerland) · 2023Article
- ROS accumulation-induced tapetal PCD timing changes leads to microspore abortion in cotton CMS lines.BMC plant biology · 2023Article
- Multi-Trait Genome-Wide Association Studies ofPathogens (Basel, Switzerland) · 2023Article
- Identification and Expression Analysis of Hexokinases Family inPlants (Basel, Switzerland) · 2023Article
- Integrated transcriptome and metabolome analysis unveil the response mechanism in wild rice (Frontiers in genetics · 2023Article
- The boundary of life and death: changes in mitochondrial and cytosolic proteomes associated with programmed cell death ofFrontiers in plant science · 2023Article
- Multi Omics Analysis Revealed a Resistance Mechanism of Tibetan Barley (Plants (Basel, Switzerland) · 2022Article
- Alternative splicing ofFrontiers in plant science · 2022Article
- Article
- Oxidative Stress-Induced Alteration of Plant Central Metabolism.Life (Basel, Switzerland) · 2021Review
- Sugar modulation of anaerobic-response networks in maize root tips.Plant physiology · 2021Article
- Article
- VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems.Frontiers in physiology · 2021Review
28 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings suggest a pivotal role for mitochondria-associated hexokinase in the regulation of apoptosis in animal cells. In this study, virus-induced gene silencing (VIGS) of a hexokinase-encoding Hxk1 caused necrotic lesions on leaves, abnormal leaf morphology, and retarded plant growth in Nicotiana benthamiana. Hxk1 was associated with the mitochondria, and this association required the N-terminal membrane anchor. VIGS of Hxk1 reduced the cellular glucose-phosphorylating activity to approximately 31% of control levels without changing the fructose-phosphorylating activity and did not alter hexose phosphate content severely. The affected cells showed programmed cell death (PCD) morphological markers, including nuclear condensation and DNA fragmentation. Similar to animal cell apoptosis, cytochrome c was released into the cytosol and caspase-9- and caspase-3-like proteolytic activities were strongly induced. Furthermore, based on flow cytometry, Arabidopsis thaliana plants overexpressing Arabidopsis HXK1 and HXK2, both of which are predominantly associated with mitochondria, exhibited enhanced resistance to H(2)O(2)- and alpha-picolinic acid-induced PCD. Finally, the addition of recombinant Hxk1 to mitochondria-enriched fractions prevented H(2)O(2)/clotrimazole-induced cytochrome c release and loss of mitochondrial membrane potential. Together, these results show that hexokinase critically regulates the execution of PCD in plant cells, suggesting a link between glucose metabolism and apoptosis.
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