ArticleBritish journal of sports medicine2006
Immunoglobulin responses to a repeated bout of downhill running.
Article in British journal of sports medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Immunological Outcomes of Bovine Colostrum Supplementation in Trained and Physically Active People: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- The effect of 12-week high-doseFrontiers in immunology · 2024Trial
- Muscle soreness but not neuromuscular fatigue responses following downhill running differ according to the number of exercise bouts.European journal of sport science · 2025Article
- Repeated Bout Effect of Downhill Running on Physiological Markers of Effort and Post Exercise Perception of Soreness in Trained Female Distance Runners.Sports (Basel, Switzerland) · 2024Article
- Multi-Micronutrient Supplementation and Immunoglobulin Response in Well-Fed Firefighters.Sports medicine international open · 2021Article
- Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review.Sports medicine (Auckland, N.Z.) · 2020Review
- Fatigue associated with prolonged graded running.European journal of applied physiology · 2016Review
- Repeated bouts of eccentrically biased endurance exercise stimulate salivary IgA secretion rate.Biology of sport · 2015Article
- Repeated muscle injury as a presumptive trigger for chronic masticatory muscle pain.Pain research and treatment · 2011Article
- Bovine colostrum supplementation and exercise performance: potential mechanisms.Sports medicine (Auckland, N.Z.) · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the effect of downhill running on immunoglobulin responses.
methodEleven untrained men performed 2 x 60 minute bouts of downhill running (-13.5% gradient), at a speed eliciting 75% of their vO2peak on a level grade. Two runs were spaced 14 days apart. Serum samples were collected before, after, and every hour for 12 hours and every 24 hours for six days. Serum total creatine kinase and immunoglobulin isotypes and subclasses were measured, and results were analysed using a repeated measures analysis of variance (12 hour period, 2 x 14; 24 hour intervals, 2 x 6, p < or = 0.05).
resultsThere was a significant interaction effect for creatine kinase (activity lower after run 2 than after run 1, 6-24 h) and exercise effect, with the serum concentrations of IgG1, IgG2, IgG4, and IgE lower, and IgM higher, after run 2.
conclusionLower concentrations of IgG1, IgG2, and IgE after run 2 may reflect a dampened autoimmune inflammatory response to autoantigens and enhanced autoantigen clearance mediated by the upregulation of IgM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.