ReviewNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2006
Biomarkers to assess the utility of potential reduced exposure tobacco products.
Review in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01692353 (Evaluation of Cardiovascular Disease Biomarkers in Exclusive Smokers and Exclusive Moist Snuff Consumers), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Cardiovascular Disease Biomarkers in Exclusive Smokers and Exclusive Moist Snuff Consumers
Who cites it
40 citing papers in PubMed.
- Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence.Scientific reports · 2022Trial
- A Randomized, Controlled Study to Assess Biomarkers of Exposure in Adult Smokers Switching to Oral Nicotine Products.Journal of clinical pharmacology · 2022Trial
- Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 3. Biomarkers of biological effect.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Trial
- Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 2. Biomarkers of exposure.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015Trial
- Public education about the relative harm of tobacco products: an intervention for tobacco control professionals.Tobacco control · 2014Trial
- Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies.Thorax · 2011Trial
- What Can Current Biomarker Data Tell Us About the Risks of Lung Cancer Posed by Heated Tobacco Products?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use.Addiction neuroscience · 2023Article
- Understanding heterogeneity among individuals who smoke cigarettes and vape: assessment of biomarkers of exposure and potential harm among subpopulations from the PATH Wave 1 Data.Harm reduction journal · 2022Article
- Review
- Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model.Archives of toxicology · 2021Article
- Electronic Cigarettes and the Lung Proteome.American journal of respiratory and critical care medicine · 2018Article
- Reply to Shields et al.: Electronic Cigarettes and the Lung Proteome.American journal of respiratory and critical care medicine · 2018Article
- Consortium on Methods Evaluating Tobacco: Research Tools to Inform US Food and Drug Administration Regulation of Snus.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Review
- Cognitive Effects of Nicotine: Recent Progress.Current neuropharmacology · 2018Review
- Day-to-Day Variability in Self-Reported Cigarettes Per Day.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Review
- Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Reference change values in concentrations of urinary and salivary biomarkers of exposure and mouth level exposure in individuals participating in an ambulatory smoking study.Practical laboratory medicine · 2016Article
- Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey.Inhalation toxicology · 2015Article
Corrections and comments
- Republished from
Authors and funding
5 authors.
Funding
Abstract
To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.