ReviewAutoimmunity reviews2006
Therapeutic implications of autoimmune vitiligo T cells.
Review in Autoimmunity reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 91 citations in OpenAlex.
- Impacts of exposure to topical calcineurin inhibitors on metabolism in vitiligo infants.Pediatric research · 2023Trial
- PD-1, BTLA and TIGIT as therapeutic targets for rheumatic disease.Nature reviews. Rheumatology · 2026Review
- Lesional CD8+ T-Cell Number Predicts Surgical Outcomes of Melanocyte-Keratinocyte Transplantation Surgery for Vitiligo.The Journal of investigative dermatology · 2023Article
- Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression.Aging · 2021Article
- The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity.Science immunology · 2021Review
- CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation.Scientific reports · 2021Article
- CCL17-CCR4 axis contributes to the onset of vitiligo in mice.Immunity, inflammation and disease · 2021Article
- Tumor rejection properties of gp100Molecular immunology · 2021Article
- Adverse events during immunotherapy in Slovenian patients with metastatic melanoma reveal a positive correlation with better treatment outcomes.Radiology and oncology · 2021Article
- Enrichment of melanoma-associated T cells in 6-thioguanine-resistant T cells from metastatic melanoma patients.Melanoma research · 2020Article
- A Concise Review on the Role of Endoplasmic Reticulum Stress in the Development of Autoimmunity in Vitiligo Pathogenesis.Frontiers in immunology · 2020Review
- Article
- The convergence theory for vitiligo: A reappraisal.Experimental dermatology · 2019Review
- IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.Frontiers in immunology · 2018Review
- Metastatic Melanoma of Uncertain Primary with 5-Year Durable Response after Conventional Therapy: A Case Report with Literature Review.Case reports in oncological medicine · 2018Article
- Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin.Pigment cell & melanoma research · 2016Article
- Article
- Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation.Pigment cell & melanoma research · 2014Article
- A quantitative increase in regulatory T cells controls development of vitiligo.The Journal of investigative dermatology · 2014Article
- Mutant HSP70 reverses autoimmune depigmentation in vitiligo.Science translational medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Vitiligo is an autoimmune disease presenting with progressive loss of skin pigmentation. The disease strikes 1% of the world population, generally during teenage years. The progressive loss of melanocytes from depigmenting vitiligo skin is accompanied by cellular infiltrates containing both CD4+ and CD8+ T lymphocytes. Infiltrating cytotoxic T cells with high affinity T cell receptors have likely escaped clonal deletion in the thymus, allowing such T cells to enter the circulation. Through the expression of CLA, these T cells home to the skin where they express type 1-cytokine profiles and mediate melanocyte apoptosis via the granzyme/perforin pathway. T cells found juxtapositionally apposed to remaining melanocytes can be isolated from the skin. Vitiligo T cells have demonstrated reactivity to antigens previously recognized as target antigens for T cells infiltrating melanoma tumors. In a comparison to existing melanoma-derived T cells, vitiligo T cells displayed superior reactivity towards melanoma cells. It is thought that genes encoding the TCRs expressed by vitiligo skin infiltrating T cells can be cloned and expressed in melanoma T cells, thereby generating a pool of circulating T cells with high affinity for their targets that can re-direct the immune response towards the tumor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.