ReviewBrain research2006
Mouse models as a tool to unravel the genetic basis for human otitis media.
Review in Brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Targeting Eustachian Tube Microenvironment: Probiotic Surfactant Utilization for Antimicrobial Peptide Secretion to Prevent Otitis Media.Probiotics and antimicrobial proteins · 2026Review
- Otitis media: recent advances in otitis media vaccine development and model systems.Frontiers in microbiology · 2024Review
- gom1 Mutant Mice as a Model of Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- STAT1 deficiency predisposes to spontaneous otitis media.PloS one · 2020Article
- Understanding the aetiology and resolution of chronic otitis media from animal and human studies.Disease models & mechanisms · 2017Review
- Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis.PloS one · 2016Article
- What have we learned from murine models of otitis media?Current allergy and asthma reports · 2013Review
- Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.PloS one · 2013Article
- Pathological features in the LmnaDhe/+ mutant mouse provide a novel model of human otitis media and laminopathies.The American journal of pathology · 2012Article
- Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.PloS one · 2012Article
- Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.The Journal of biological chemistry · 2011Article
- Article
- A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.Nature protocols · 2010Article
- The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Mouse models for human otitis media.Brain research · 2009Review
- Review
- Can you hear me now? A genetic model of otitis media with effusion.The Journal of clinical investigation · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The pathogenesis of otitis media (OM) is multifactorial and includes infection, anatomical factors, immunologic status, genetic predisposition, and environmental factors. OM remains the most common cause of hearing impairment in childhood. Genetic predisposition is increasingly recognized as an important factor. The completion of the mouse genome sequence has offered a powerful basket of tools for investigating gene function and can expect to generate a rich resource of mouse mutants for the elucidation of genetic factors underlying OM. We review the literature and discuss recent progresses in developing mouse models and using mouse models to uncover the genetic basis for human OM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.