ArticleArteriosclerosis, thrombosis, and vascular biology2006
Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α.Molecular and cellular biochemistry · 2024Review
- Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells.International journal of molecular sciences · 2017Article
- Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model.Journal of vascular research · 2014Article
- Epoxides and soluble epoxide hydrolase in cardiovascular physiology.Physiological reviews · 2012Review
- Cytochrome P450 eicosanoids and cerebral vascular function.Expert reviews in molecular medicine · 2011Review
- Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.Biochemical pharmacology · 2010 · on this mapArticle
- Soluble epoxide hydrolase inhibition modulates vascular remodeling.American journal of physiology. Heart and circulatory physiology · 2010Article
- Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.The American journal of pathology · 2009Article
- PPARs and the cardiovascular system.Antioxidants & redox signaling · 2009Review
- Arachidonic acid cytochrome P450 epoxygenase pathway.Journal of lipid research · 2009Review
- Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveProliferation of smooth muscle cells is implicated in cardiovascular complications. Previously, a urea-based soluble epoxide hydrolase inhibitor was shown to attenuate smooth muscle cell proliferation. We examined the possibility that urea-based alkanoic acids activate the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) and the role of PPARalpha in smooth muscle cell proliferation. METHODS AND
resultsAlkanoic acids transactivated PPARalpha, induced binding of PPARalpha to its response element, and significantly induced the expression of PPARalpha-responsive genes, showing their function as PPARalpha agonists. Furthermore, the alkanoic acids attenuated platelet-derived growth factor-induced smooth muscle cell proliferation via repression of cyclin D1 expression. Using small interfering RNA to decrease endogenous PPARalpha expression, it was determined that PPARalpha was partially involved in the cyclin D1 repression. The antiproliferative effects of alkanoic acids may also be attributed to their inhibitory effects on soluble epoxide hydrolase, because epoxyeicosatrienoic acids alone inhibited smooth muscle cell proliferation.
conclusionsThese results show that attenuation of smooth muscle cell proliferation by urea-based alkanoic acids is mediated, in part, by the activation of PPARalpha. These acids may be useful for designing therapeutics to treat diseases characterized by excessive smooth muscle cell proliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.