ArticleThe EMBO journal1990
Cyclic hair-loss and regrowth in transgenic mice overexpressing an intermediate filament gene.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 93 citations in OpenAlex.
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Wool: From Properties and Structure to Genetic Insights and Sheep Improvement Strategies.Animals : an open access journal from MDPI · 2025Review
- Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice.Molecular and cellular biology · 2005Article
- Hox in hair growth and development.Die Naturwissenschaften · 2003Review
- Article
- Functional differences between keratins of stratified and simple epithelia.The Journal of cell biology · 1998Article
- Expression of a wool intermediate filament keratin transgene in sheep fibre alters structure.Transgenic research · 1998Article
- Hoxc13 mutant mice lack external hair.Genes & development · 1998Article
- Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.Molecular biology of the cell · 1997Review
- The commercial and agricultural applications of animal transgenesis.Molecular biotechnology · 1995Review
- Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.The Journal of cell biology · 1994Article
- Intermediate filaments and disease: mutations that cripple cell strength.The Journal of cell biology · 1994Review
- Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.The Journal of cell biology · 1993Article
- Analysis of the sheep trichohyalin gene: potential structural and calcium-binding roles of trichohyalin in the hair follicle.The Journal of cell biology · 1993Article
- A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.The Journal of cell biology · 1991Article
- The genetic engineering of production traits in domestic animals.Experientia · 1991Review
- Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles.The Journal of cell biology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have produced transgenic mice containing up to 250 copies of a sheep wool intermediate filament keratin gene to study the effect of its expression on hair structure and development. Several transgenic lines expressed the gene and in the one containing 250 transgenes, a pattern of hair-loss and regrowth was stably established. Successive waves of hair growth follow periods of denuding like the natural progression of hairs in the mouse hair cycle. By in situ hybridization we have shown that the sheep transgenes are expressed at the correct stage in mouse hair development and at a high level. The transgenic hairs contain not only an elevated level of intermediate filament keratin protein but also a decreased level of the filament-associated proteins. This imbalance disrupts the normal ordered array of these proteins in the cells of the hair cortex and leads to weakened fibres which are prematurely lost.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.