ArticleJournal of clinical pathology2007
Differential distribution of inflammatory cells in large and small airways in smokers.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- [Prospective evaluation of the efficacy of the combination of budesonide/formoterol in obstructive airway disease after allogeneic hematopoietic stem cell transplantation].Revue des maladies respiratoires · 2009Trial
- Utility of an artificial intelligence-based lung CT airway model in the quantitative evaluation of large and small airway lesions in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- Quantitative analysis of lung function and airway remodeling using ventilation/perfusion single photon emission tomography/computed tomography and HRCT in patients with chronic obstructive pulmonary disease and asthma.Annals of nuclear medicine · 2023Article
- Anoikis resistance of small airway epithelium is involved in the progression of chronic obstructive pulmonary disease.Frontiers in immunology · 2023Article
- Relationships between Airway Remodeling and Clinical Characteristics in COPD Patients.Biomedicines · 2022Article
- The pathology of small airways disease in COPD: historical aspects and future directions.Respiratory research · 2019Review
- Regional heterogeneity in response of airway epithelial cells to cigarette smoke.BMC pulmonary medicine · 2018Article
- Article
- Adhesion molecules in subjects with COPD and healthy non-smokers: a cross sectional parallel group study.Respiratory research · 2013Article
- High levels of lung resident CD4+CD28null cells in COPD: implications of autoimmunity.Wiener klinische Wochenschrift · 2013Article
- A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.The Journal of allergy and clinical immunology · 2013Article
- A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.Bioinformatics and biology insights · 2013Article
- Leptin, adiponectin and pulmonary diseases.Biochimie · 2012Review
- Systemic inflammation in COPD in relation to smoking status.Multidisciplinary respiratory medicine · 2011Article
- Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients.Journal of inflammation (London, England) · 2010Article
- Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters.Respiratory research · 2010Article
- Association of mast cells with lung function in chronic obstructive pulmonary disease.Respiratory research · 2008Article
- Induction of lung emphysema is prevented by L-arginine-threonine-arginine.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Combined inhaled steroids and bronchodilatators in obstructive airway disease after allogeneic stem cell transplantation.Bone marrow transplantation · 2007Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmoking induces structural changes in the airways, and is considered a major factor in the development of airflow obstruction in chronic obstructive pulmonary disease. However, differences in inflammatory cell distribution between large airways (LA) and small airways (SA) have not been systematically explored in smokers. HYPOTHESIS: The content of cells infiltrating the airway wall differs between LA and SA.
aimsTo compare the content of neutrophils, macrophages, lymphocytes and mast cells infiltrating LA and SA in smokers who underwent surgery for lung cancer.
methodsLung tissue from 15 smokers was analysed. Inflammatory cells in the lamina propria were identified by immunohistochemical analysis, quantified by digital image analysis and expressed as number of cells per surface area.
resultsThe number of neutrophils infiltrating the lamina propria of SA (median 225.3 cells/mm(2)) was higher than that in the lamina propria of LA (median 60.2 cells/mm(2); p<0.001). Similar results were observed for mast cells: 313.3 and 133.7 cells/mm(2) in the SA and LA, respectively (p<0.001). In contrast, the number of CD4 cells was higher in LA compared with SA (median 217.8 vs 80.5 cells/mm(2); p = 0.042).
conclusionsThese findings indicate a non-uniform distribution of neutrophils and mast cells throughout the bronchial tree, and suggest that these cells may be involved in the development of smoking-related peripheral lung injury.
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