Evidence map›Paper›PMID 16916912›Full record

ReviewThe Journal of physiology2006

Ca2+ signalling in urethral interstitial cells of Cajal.

Gerard P Sergeant, M A Hollywood, N G McHale, K D Thornbury

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Calcium Signaling in Interstitial Cells: Focus on Telocytes.International journal of molecular sciences · 2017
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Smooth muscle cell calcium activation mechanisms.The Journal of physiology · 2008
    Review
  10. Article
  11. Article
  12. The importance of interstitial cells of cajal in the gastrointestinal tract.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gerard P SergeantSmooth Muscle Research Centre, Regional Development Centre, Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland. gerard.sergeant@dkit.ie
M A Hollywood
N G McHale
K D Thornbury
Dundalk Institute of Technology · IE

Funding

Myogenic tone in the urethra and its modulationR01DK068565 · NIDDK · DUNDALK INSTITUTE OF TECHNOLOGY · PI HOLLYWOOD, MARK A · 2005 to 2009
$1.1M
NIDDK NIH HHS R01 DK068565NIDDK NIH HHS R01 DK68565Wellcome TrustWellcome Trust 064212
6 · The paper itself

Abstract

Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and therefore the maintenance of urinary continence. Recent studies on freshly dispersed ICC from the urethra of rabbits have demonstrated that pacemaker activity in urethra ICC is characterized by spontaneous transient depolarizations (STDs) under current clamp and spontaneous transient inward currents (STICs) under voltage clamp. When these events were simultaneously recorded with changes in intracellular Ca(2+) (using a Nipkow spinning disk confocal microscope) they were found to be associated with global Ca(2+) oscillations. In this short review we will consider some of these recent findings regarding the contribution of intracellular Ca(2+) stores and Ca(2+) influx to the generation of pacemaker activity in urethral ICC with particular emphasis on the contribution of reverse Na(+)/Ca(2+) exchange (NCX).

Indexed as

AnimalsBiological ClocksCalciumMembrane PotentialsMuscle, SmoothPatch-Clamp TechniquesRabbitsSignal TransductionSodium-Calcium ExchangerUrethraCalciumSodium-Calcium Exchanger

Identifiers

PMID16916912
PMCPMC1890406
OpenAlexW2169575863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.