Trial reportThe Journal of physiology2006
Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress.
Trial report in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Trial
- Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women.American journal of physiology. Endocrinology and metabolism · 2009Trial
- Progressive baroreflex dysfunction and hypotension preceding VVS: a vicious cycle?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS-CoV-2 infection.Physiological reports · 2022Article
- The reciprocal relationship between cardiac baroreceptor sensitivity and cerebral autoregulation during simulated hemorrhage in humans.Autonomic neuroscience : basic & clinical · 2022Review
- Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Acute effects of sublingual nitroglycerin on cardiovagal and sympathetic baroreflex sensitivity.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope.Journal of clinical medicine · 2019Article
- Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects.Journal of clinical medicine · 2019Article
- Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Simultaneous Characterization of Sympathetic and Cardiac Arms of the Baroreflex through Sequence Techniques during Incremental Head-Up Tilt.Frontiers in physiology · 2016Article
- Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Sex comparisons in muscle sympathetic nerve activity and arterial pressure oscillations during progressive central hypovolemia.Physiological reports · 2015Article
- Blood pressure regulation II: what happens when one system must serve two masters--oxygen delivery and pressure regulation?European journal of applied physiology · 2014Review
- Validation of lower body negative pressure as an experimental model of hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Role of sympathetic nerve activity in the process of fainting.Frontiers in physiology · 2014Review
- Resting sympathetic baroreflex sensitivity in subjects with low and high tolerance to central hypovolemia induced by lower body negative pressure.Frontiers in physiology · 2014Article
- Disruption of phase synchronization between blood pressure and muscle sympathetic nerve activity in postural vasovagal syncope.American journal of physiology. Heart and circulatory physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that arterial baroreflex (ABR)-mediated beat-to-beat control over muscle sympathetic nerve activity (MSNA) is progressively modulated as orthostatic stress increases in humans, but that this control becomes impaired just before the onset of orthostatic syncope. In 17 healthy subjects, the ABR control over MSNA (burst incidence, burst strength and total MSNA) was evaluated by analysing the relationship between beat-to-beat spontaneous variations in diastolic blood pressure (DAP) and MSNA during supine rest (control) and during progressive, stepwise increases in lower body negative pressure (LBNP) that were incremented by -10 mmHg every 5 min until presyncope (nine subjects) or -60 mmHg was reached. (1) The linear relationships between DAP and burst strength and between DAP and total MSNA were shifted progressively upward as LBNP increased until the level at which syncope occurred. The relationship between DAP and burst incidence, however, gradually shifted upward from control only to LBNP = -30 mmHg; there was no further upward shift at higher LBNPs. (2) Although the slope of the relationship between DAP and burst strength and between DAP and total MSNA remained constant at all LBNPs tested, except at the level where syncope occurred, the slope of the relationship between DAP and burst incidence was reduced at LBNPs of -40 mmHg and higher (versus control). (3) In syncopal subjects, the slopes of the relationships between DAP and burst incidence, burst strength, and total MSNA were all substantially reduced during the 1-2 min period prior to the onset of syncope. Taken together, these results suggest baroreflex control over MSNA is progressively modulated as orthostatic stress increases, so that its sensitivity is substantially reduced during the period immediately preceding the severe hypotension associated with orthostatic syncope.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.