ArticleBMC bioinformatics2006
Incorporating background frequency improves entropy-based residue conservation measures.
Article in BMC bioinformatics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
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- Sequence to structure analysis of the ORF4 protein from Hepatitis E virus.Bioinformation · 2021Article
- APOD: accurate sequence-based predictor of disordered flexible linkers.Bioinformatics (Oxford, England) · 2020Article
- Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins.Frontiers in genetics · 2019Article
- Functional and structural characterization of osteocytic MLO-Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro.Scientific reports · 2018Article
- Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions.International journal of molecular sciences · 2017Article
- Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology.Scientific reports · 2017Article
- Development of a protein-ligand-binding site prediction method based on interaction energy and sequence conservation.Journal of structural and functional genomics · 2016Article
- ASAP: a machine learning framework for local protein properties.Database : the journal of biological databases and curation · 2016Article
- Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life.Cellular and molecular life sciences : CMLS · 2015Article
- SNBRFinder: A Sequence-Based Hybrid Algorithm for Enhanced Prediction of Nucleic Acid-Binding Residues.PloS one · 2015Article
- Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis.American journal of human genetics · 2014Article
- H2rs: deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments.BMC bioinformatics · 2014Article
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2 authors.
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Abstract
backgroundSeveral entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may correlate with structurally or functionally important residues. However, amino acid background frequencies are usually not taken into account in these entropy-based scoring schemes.
resultsWe demonstrate that using a relative entropy measure that incorporates amino acid background frequency results in improved performance in identifying functional sites from protein multiple sequence alignments.
conclusionOur results suggest that the application of appropriate background frequency information may lead to more biologically relevant results in many areas of bioinformatics.
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