ReviewDifferentiation; research in biological diversity2006
From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis.
Review in Differentiation; research in biological diversity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Article
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Venom gland organogenesis in the common house spider.Scientific reports · 2024Article
- A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.Nature communications · 2024Article
- Molecular mechanisms of tubulogenesis revealed in the sea star hydro-vascular organ.Nature communications · 2023Article
- The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi.Frontiers in cell and developmental biology · 2023Article
- Apocrine secretion in the salivary glands ofFrontiers in cell and developmental biology · 2022Article
- Forced into shape: Mechanical forces in Drosophila development and homeostasis.Seminars in cell & developmental biology · 2021Review
- Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model.Journal of innate immunity · 2021Article
- Review
- NM23 proteins: innocent bystanders or local energy boosters for CFTR?Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Cellular systems for epithelial invagination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade.PLoS genetics · 2015Article
- Article
- Tip cells: master regulators of tubulogenesis?Seminars in cell & developmental biology · 2014Review
- Anatomy, biogenesis and regeneration of salivary glands.Monographs in oral science · 2014Review
- The secreted AdamTS-A metalloprotease is required for collective cell migration.Development (Cambridge, England) · 2013Article
- Fosmid-based structure-function analysis reveals functionally distinct domains in the cytoplasmic domain of Drosophila crumbs.G3 (Bethesda, Md.) · 2013Article
- A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.Nature cell biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Tube formation is a ubiquitous process required to sustain life in multicellular organisms. The tubular organs of adult mammals include the lungs, vasculature, digestive and excretory systems, as well as secretory organs such as the pancreas, salivary, prostate, and mammary glands. Other tissues, including the embryonic heart and neural tube, have requisite stages of tubular organization early in development. To learn the molecular and cellular basis of how epithelial cells are organized into tubular organs of various shapes and sizes, investigators have focused on the Drosophila trachea and salivary gland as model genetic systems for branched and unbranched tubes, respectively. Both organs begin as polarized epithelial placodes, which through coordinated cell shape changes, cell rearrangement, and cell migration form elongated tubes. Here, we discuss what has been discovered regarding the details of cell fate specification and tube formation in the two organs; these discoveries reveal significant conservation in the cellular and molecular events of tubulogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.