SynthesisPsychopharmacology2006
Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature.
Synthesis in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- The serotonin theory of depression: a systematic umbrella review of the evidence.Molecular psychiatry · 2023Pooled it
- Revisiting the serotonin-aggression relation in humans: a meta-analysis.Psychological bulletin · 2013Pooled it
- The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023Trial
- Acute tryptophan loading decreases functional connectivity between the default mode network and emotion-related brain regions.Human brain mapping · 2019Trial
- Time series fMRI measures detect changes in pontine raphé following acute tryptophan depletion.Psychiatry research · 2011Trial
- Trial
- Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure.Psychopharmacology · 2009Trial
- Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stress.Psychopharmacology · 2008Trial
- Effect of tryptophan depletion on the attentional salience of smoking cues.Psychopharmacology · 2007Trial
- Acute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa.Journal of psychiatry & neuroscience : JPNTrial
- Urine 5-HIAA and quality of life in neuroendocrine neoplasia. Is there an association?Rare tumors · 2026Article
- Tryptophan-induced effects on the behavior and physiology of aging in tryptophan hydroxylase-2 heterozygous mice C57BL/6N.Veterinary world · 2025Article
- Fifty years on: Serotonin and depression.Journal of psychopharmacology (Oxford, England) · 2023Review
- A Predictive Coding Framework for Understanding Major Depression.Frontiers in human neuroscience · 2022Review
- Cognitive Control as a 5-HTFrontiers in psychology · 2019Article
- Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion.Cognitive, affective & behavioral neuroscience · 2012Article
- Mechanism of acute tryptophan depletion: is it only serotonin?Molecular psychiatry · 2011Review
- 5-HT modulation by acute tryptophan depletion of human instrumental contingency judgements.Psychopharmacology · 2011Article
- Serotonin, genetic variability, behaviour, and psychiatric disorders--a review.Upsala journal of medical sciences · 2010Review
- L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications.International journal of tryptophan research : IJTR · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThere is a growing psychopharmacological literature on the use of Acute Tryptophan Depletion (ATD) for experimental modulation of the serotonergic system. To date, no systematic review has been undertaken assessing the neurophysiological effects following this acute central 5-HT manipulation. MATERIALS AND
methodsA comprehensive MEDLINE, EMBASE, PsycINFO search was performed for reports on neural substrates of Acute Tryptophan Depletion in healthy individuals and in clinical population.
resultsTwenty-eight placebo-controlled studies were included in the review. Although tryptophan depletion reduced plasma serotonin levels in all studies, significant effects on mood were only observed in studies with recovered depressed patients. In functional neuroimaging studies ATD was consistently found to modulate cortical activity in prefrontal areas implicated in mnemonic and executive functions and in orbitofrontal, cingulate, and subcortical regions associated with emotional processing. Electrophysiological studies indicated that ATD has a significant effect on both "selective" and "involuntary" attention.
conclusionsThe combination of ATD with modern brain imaging techniques allows the investigation of the neurophysiological effects of reduced 5-HT synthesis on global brain activity, executive functions, memory, attention, and affect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.