ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Electrical coupling between locomotor-related excitatory interneurons in the mammalian spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 90 citations in OpenAlex.
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- Patterns of connexin36 and eGFP reporter expression among motoneurons in spinal sexually dimorphic motor nuclei in mouse.International journal of physiology, pathophysiology and pharmacology · 2024Article
- Synaptic Projections of Motoneurons Within the Spinal Cord.Advances in neurobiology · 2022Article
- Recent Insights into the Rhythmogenic Core of the Locomotor CPG.International journal of molecular sciences · 2021Review
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- Gap Junctions Between Striatal D1 Neurons and Cholinergic Interneurons.Frontiers in cellular neuroscience · 2021Article
- Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.Frontiers in neural circuits · 2020Article
- The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.Current opinion in physiology · 2019Article
- Dye-coupling between neonatal spinal motoneurons and interneurons revealed by prolonged back-filling of a ventral root with a low molecular weight tracer in the mouse.Scientific reports · 2019Article
- Mapping Connectivity Amongst Interneuronal Components of the Locomotor CPG.Frontiers in cellular neuroscience · 2019Article
- Article
- Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.Cell reports · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- SK channel inhibition mediates the initiation and amplitude modulation of synchronized burst firing in the spinal cord.Journal of neurophysiology · 2017Article
- Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.Scientific reports · 2017Article
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- The central pattern generator underlying swimming in Dendronotus iris: a simple half-center network oscillator with a twist.Journal of neurophysiology · 2016Article
- Review
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Locomotor rhythm generation is a fundamental characteristic of neural networks in the spinal cord. Identifying the synaptic interactions between neurons in the locomotor circuitry is key to our understanding of the mechanisms that underlie the production of rhythmic motor outputs. Using transgenic mice in which the homeobox gene HB9 drives the reporter green fluorescent protein (GFP), we have demonstrated that a genetically distinct cluster of Hb9/GFP-expressing interneurons (Hb9 INs) can generate locomotor-like rhythms in the newborn mouse spinal cord (Hinckley et al., 2005b). Processes of Hb9 INs are in close apposition to adjacent Hb9 INs, raising the possibility that the interneurons are synaptically interconnected. To test this hypothesis, whole-cell paired recordings were performed from visually identified Hb9 INs. High-incidence bidirectional electrical coupling was evident between Hb9 INs in spinal cords of newborn and juvenile mice. The coupling strength varied from 2 to 32% with an average of 12%. Our data suggested that the variability was not correlated with the distribution of electrical synapses at different electronic distances. Electrical synapses behaved as low-pass filters, reducing currents passing at frequencies >3 Hz. Episodes of spontaneous bursts of EPSCs were synchronous in coupled Hb9 INs, indicating that common synaptic inputs coordinated their activity. However, non-NMDA receptor-mediated synaptic transmission was not required to synchronize neurochemically induced membrane oscillations between electrically coupled interneurons. The finding that electrical transmission persists in mice that can walk is indicative of its importance in coordinating the activity of this neuronal population in functionally mature spinal networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.