ReviewSchizophrenia bulletin2006
The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?
Review in Schizophrenia bulletin, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Clinical and molecular genetics of psychotic depression.Schizophrenia bulletin · 2013Review
- Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2011Article
- N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals.Human brain mapping · 2011Article
- The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach.BMC psychiatry · 2010Article
- Searching for valid psychiatric phenotypes: discrete latent variable models.International journal of methods in psychiatric research · 2010Article
- New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?Frontiers in behavioral neuroscience · 2010Article
- Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects.BMC psychiatry · 2009Article
- Schizopsychotic symptom-profiles and biomarkers: beacons in diagnostic labyrinths.Neurotoxicity research · 2008Review
- Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance.Schizophrenia research · 2008Article
- Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder.Molecular psychiatry · 2008Article
- Which perspectives can endophenotypes and biological markers offer in the early recognition of schizophrenia?Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus which harbors the genes G72 and G30. These association findings have been replicated in several independent schizophrenia samples. Association has also been found between genetic variants at the G72/G30 locus and bipolar affective disorder (BPAD), with replication in independent studies. Results from studies of more detailed psychiatric phenotypes show that association exists with symptom clusters that are common to several disorders as well as with specific psychiatric diagnoses. These findings may indicate that the association lies not with the diagnostic categories per se but with more specific aspects of the phenotype, such as affective symptoms and cognitive effects, which cross traditional psychiatric diagnostic boundaries. At the molecular level, the picture remains far from clear. No putative functional variants have been identified in the coding regions of G72 or G30, and it is therefore likely that disease susceptibility is caused by as yet unidentified variants which alter gene expression or splicing. A further complication is the fact that inconsistencies are evident in the risk alleles and haplotypes observed to be associated across different samples and studies, which may suggest the presence of multiple susceptibility variants at this locus. Functional analyses indicate that the G72 gene product plays a role in the activation of N-methyl-D-aspartate receptors, a molecular pathway implicated in both schizophrenia and BPAD, making it the most plausible candidate gene at this locus.
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