ArticleThe journal of physical chemistry. B2006
Defects can increase the melting temperature of DNA-nanoparticle assemblies.
Article in The journal of physical chemistry. B, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- GSH/pH-Responsive Chitosan-PLA Hybrid Nanosystems for Targeted Ledipasvir Delivery to HepG2 Cells: Controlled Release, Improved Selectivity, DNA Interaction, Electrochemical and Stopped-Flow Kinetics Analyses.International journal of molecular sciences · 2025Article
- Analysis of Recent Bio-/Nanotechnologies for Coronavirus Diagnosis and Therapy.Sensors (Basel, Switzerland) · 2021Review
- Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.Cell & bioscience · 2013Article
- Free energy considerations for nucleic acids with dangling ends near a surface: a coarse grained approach.Journal of physics. Condensed matter : an Institute of Physics journal · 2011Article
- A model for Structure and Thermodynamics of ssDNA and dsDNA Near a Surface: a Coarse Grained Approach.Computer physics communications · 2010Article
- Kinetics and thermodynamics of DNA hybridization on gold nanoparticles.Nucleic acids research · 2009Article
- Phase Transition and Optical Properties of DNA-Gold Nanoparticle Assemblies.Plasmonics (Norwell, Mass.) · 2007Article
- Using theory and computation to model nanoscale properties.Proceedings of the National Academy of Sciences of the United States of America · 2007Review
- An in vitro selection scheme for oligonucleotide probes to discriminate between closely related DNA sequences.Nucleic acids research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable detection technology. We studied the effects of DNA base-pairing defects, such as mismatches and deletions, on the melting temperature of DNA-nanoparticle assemblies. We found that, contrary to the general assumption that defects lower the melting temperature of DNA, some defects increase the melting temperature of DNA-linked nanoparticle assemblies. The effects of mismatches and deletions were found to depend on the specific base pair, the sequence, and the location of the defects. Our results demonstrate that the surface-bound DNA exhibit hybridization behavior different from that of free DNA. Such findings indicate that a detailed understanding of DNA-nanoparticle assembly phase behavior is required for quantitative interpretation of DNA-nanoparticle aggregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.