ArticleJournal of virology1990
Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus.
Article in Journal of virology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Methodological landscape in the field of integration site identification of retroviruses and retroviral vectors.Frontiers in bioengineering and biotechnology · 2025Review
- Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.Scientific reports · 2021Article
- Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model.Oncotarget · 2017Article
- Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.Immunology · 2009Review
- What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas.Leukemia · 2002Review
- The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.Journal of virology · 2000Article
- Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemia.Oncogene · 1999Article
- Localization of a Moloney murine leukemia virus integration site gene, Mlvi2, on rat chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Identification of two enhancer elements downstream of the human c-myc gene.Nucleic acids research · 1995Article
- Long terminal repeat enhancer core sequences in proviruses adjacent to c-myc in T-cell lymphomas induced by a murine retrovirus.Journal of virology · 1995Article
- The activated Mlvi-4 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas encodes an env/Mlvi-4 fusion protein.Journal of virology · 1994Article
- The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Genetic mapping of the gene coding for the integrin beta 7 subunit to the distal part of mouse chromosome 15.Immunogenetics · 1992Article
- Mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.American journal of human genetics · 1991Article
- Mouse map of paralogous genes.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
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10 authors.
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Abstract
Moloney murine leukemia virus-induced rat T-cell lymphomas harbor proviruses integrated near c-myc and near Mlvi-1/Mis-1/Pvt-1, another locus of common integration which maps 270 kilobases 3' of c-myc. In this report, we present the characterization of a new locus of common integration in Moloney murine leukemia virus-induced T-cell lymphomas (Mlvi-4) which maps 30 kilobases 3' of c-myc, between c-myc and Mlvi-1. The Mlvi-4 locus, whose chromosomal map location is conserved in rats, mice, and humans, is also the target of chromosomal rearrangements in a variety of animal and human tumors. Evidence presented elsewhere shows that provirus integration in Mlvi-4 enhances the expression of c-myc and Mlvi-1 by cis-acting mechanisms operating over long distances of genomic DNA. In this manuscript, we show that provirus integration in the Mlvi-4 locus activates, by promoter insertion, one additional gene which maps immediately 3' to the cluster of the Mlvi-4 proviruses and which is transcribed in the same orientation as c-myc, giving rise to 3- and 10-kilobase mRNA transcripts. The Mlvi-4 gene is also expressed in normal thymus and spleen at very low levels, giving rise to 3- and 5.5-kilobase messages. Although Mlvi-4 is expressed in normal thymus, it is not expressed in Moloney murine leukemia virus-induced T-cell lymphomas corresponding to several stages of T-cell differentiation, but lacking a provirus in this locus. This suggests that Mlvi-4 may be expressed only in a subpopulation of T cells. We conclude that provirus insertion in Mlvi-4 activates c-myc and two additional genes, Mlvi-1 and Mlvi-4, whose expression is restricted to, and may be developmentally regulated in, T cells. Since Mlvi-4 is the target of genetic changes in a great variety of human and animal neoplasms, these results are critical for our understanding of oncogenesis.
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