ArticleCroatian medical journal2006
Overview of genetic-epidemiological studies in ethnically and demographically diverse isolates of Dagestan, Northern Caucasus, Russia.
Article in Croatian medical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Polymorphisms in Factor II and Factor V thrombophilia genes among Circassians in Jordan.Journal of thrombosis and thrombolysis · 2013Trial
- Genetic Characteristics of a Large Pediatric Cohort of Patients with Inborn Errors of Immunity: Single-Center Experience.Journal of clinical immunology · 2024Article
- Epidemiology and Genetics of Mucopolysaccharidosis Type VI in Russia.Frontiers in molecular biosciences · 2021Article
- Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations.PeerJ · 2017Article
- Extensive genome-wide autozygosity in the population isolates of Daghestan.European journal of human genetics : EJHG · 2015Article
- CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations.Scientific reports · 2015Article
- Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.PloS one · 2011Article
- Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Health effects of human population isolation and admixture.Croatian medical journal · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess genetic diversity and genetic distances among isolated populations from Dagestan.
methodsA cross-population genetic epidemiology design was applied in ethnically and demographically diverse isolates from Dagestan, some with more than 200 and some with less than 100 generations of demographical history since their founding.
resultsThe analysis of genetic diversity showed that Dagestan ethnic populations are clearly close to European ethnic populations. The genetic data support the view of them as ancient, highly isolated populations 85%-97% the rate of the endogamy and inbreeding coefficient F=0.010-0.015. Many Dagestan populations have very high prevalence of certain complex diseases such as cardiovascular illnesses, cancer, schizophrenia, mental retardation, and progressive muscular dystrophy. Lifetime morbid risk for schizophrenia in the isolates varied from 0 to 5%. Among the relatives, the number of men with chronic schizophrenia was at least twice as high as women. The average age of onset of schizophrenia was 21.2 years for offspring of consanguineous marriages and 17.4 years for offspring of non-consanguineous marriages (P=0.033).
conclusionThe results support the hypothesis that cross-population design provides unique opportunities for observing reliable ancestral haplotypes with disease predisposing loci, as well as population-specific linked loci.
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16912990PMC2080444W2161560358What OpenQuestion holds
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