ArticleVirchows Archiv : an international journal of pathology2006
Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Synbiotic2000™ Forte on the Intestinal Motility and Interstitial Cells of Cajal in TBI Mouse Model.Probiotics and antimicrobial proteins · 2017Article
- Stem Cell Factor/Kit Signal Insufficiency Contributes to Hypoxia-Induced Intestinal Motility Dysfunctions in Neonatal Mice.Digestive diseases and sciences · 2017Article
- Therapeutic effect and mechanism of electroacupuncture at Zusanli on plasticity of interstitial cells of Cajal: a study of rat ileum.BMC complementary and alternative medicine · 2014Article
- Article
- Characterization of interstitial Cajal progenitors cells and their changes in Hirschsprung's disease.PloS one · 2014Article
- The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut.Journal of neurogastroenterology and motility · 2014Review
- Article
- Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging.Neurogastroenterology and motility · 2011Article
- Pyloric resection and delayed gastric liquid emptying in rats.Digestive diseases and sciences · 2011Article
- Adenovirus-mediated stem cell leukemia gene transfer induces rescue of interstitial cells of Cajal in ICC-loss mice.International journal of colorectal disease · 2010Article
- Bone marrow derivation of interstitial cells of cajal in small intestine following intestinal injury.Journal of biomedicine & biotechnology · 2010Article
- Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.Gastroenterology · 2009Review
- Apoptosis of interstitial cells of Cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult guinea pigs.Virchows Archiv : an international journal of pathology · 2009Article
- An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice.Histochemistry and cell biology · 2009Article
- Alterations in the density of interstitial cells of Cajal in achalasia.Digestive diseases and sciences · 2008Article
- Progenitors of interstitial cells of cajal in the postnatal murine stomach.Gastroenterology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical manipulations of the gastrointestinal (GI) tract usually lead to loss of interstitial cells of Cajal (ICCs). The present study prepared to investigate whether ICCs can regenerate and restore their normal distribution up to 5 months after semitransection and end-to-end anastomosis of small intestines of adult guinea pigs. The segments of anastomosis were studied by immunohistochemistry with anti-KIT, 5-bromo-2'-deoxyuridine (BrdU), stem cell factor (SCF), and neurofilament 200 antibodies and also by transmission electron microscopy (TEM). At early stage, intestinal surgery led to intestinal wall impairment and ICCs loss, and ICCs near the site of anastomosis gradually increased in numbers. About 150 days postoperation, the distribution of ICCs and the microstructure of intestinal wall appeared to be similar with those of the control. By double immunostaining with BrdU and KIT antibodies, a number of proliferated ICCs were seen near the site of transection/anastomosis. Furthermore, KIT ligand, SCF, was mainly observed in the smooth muscle cells (SMCs), which are located close to ICCs. TEM observation revealed a number of immature and mature ICCs in this region. Our results indicated that ICCs could regenerate and restore their normal distribution after intestinal surgery and SMCs might be involved in the regenerated events of ICCs in the adult guinea pig GI tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.