ArticleEuropean biophysics journal : EBJ2007
Interaction of poly(L-lysines) with negatively charged membranes: an FT-IR and DSC study.
Article in European biophysics journal : EBJ, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Interactions of Galloylated Polyphenols with a Simple Gram-Negative Bacterial Membrane Lipid Model.Membranes · 2024Article
- Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model.Materials (Basel, Switzerland) · 2021Review
- Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials.International journal of molecular sciences · 2020Article
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- Differential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats.Frontiers in genetics · 2015Article
- Long and short lipid molecules experience the same interleaflet drag in lipid bilayers.Physical review letters · 2013Article
- A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.The Journal of biological chemistry · 2012Article
- Hydrophobicity drives the cellular uptake of short cationic peptide ligands.European biophysics journal : EBJ · 2011Article
- Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions.Journal of pharmacy & bioallied sciences · 2011Article
- Membrane chemical stability and seed longevity.European biophysics journal : EBJ · 2010Article
- Coupled diffusion of peripherally bound peptides along the outer and inner membrane leaflets.Biophysical journal · 2009Article
- Quantification of the force of nanoparticle-cell membrane interactions and its influence on intracellular trafficking of nanoparticles.Biomaterials · 2008Article
- A novel RNA-binding protein associated with cell plate formation.Plant physiology · 2008Article
- Influence of poly(L-lysine) on the structure of dipalmitoylphosphatidylglycerol/water dispersions studied by X-ray scattering.European biophysics journal : EBJ · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of the binding of poly(L-lysine) (PLL) to negatively charged membranes containing phosphatidylglycerols (PG) was studied by DSC and FT-IR spectroscopy. We found a general increase in the main transition temperature as well as increase in hydrophobic order of the membrane upon PLL binding. Furthermore we observed stronger binding of hydration water to the lipid head groups after PLL binding. The secondary structure of the PLL after binding was studied by FT-IR spectroscopy. We found that PLL binds in an alpha-helical conformation to negatively charged DPPG membranes or membranes with DPPG-rich domains. Moreover we proved that PLL binding induces domain formation in the gel state of mixed DPPC/DPPG or DMPC/DPPG membranes as well as lipid remixing in the liquid-crystalline state. We studied these effects as a function of PLL chain length and found a significant dependence of the secondary structure, phase transition temperature and domain formation capacity on PLL chain length and also a correlation between the peptide secondary structure and the phase transition temperature of the membrane. We present a system in which the membrane phase transition triggers a highly cooperative secondary structure transition of the membrane-bound peptide from alpha-helix to random coil.
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