ArticleJournal of virology2006
Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
46 citing papers in PubMed, 71 citations in OpenAlex.
- T Cell Resistance: On the Mechanisms of T Cell Non-activation.Immune network · 2024Review
- Intracellular checkpoints for NK cell cancer immunotherapy.Frontiers of medicine · 2024Review
- Immune Cell Dynamics in EGFR-Mutated NSCLC Treated With Afatinib and Pembrolizumab: Results From a Phase IB Study.JTO clinical and research reports · 2024Article
- CD83 expression characterizes precursor exhausted T cell population.Communications biology · 2023Article
- Molecular and temporal control of restimulation-induced cell death (RICD) in T lymphocytes.Frontiers in cell death · 2023Article
- Not-so-opposite ends of the spectrum: CD8Nature immunology · 2021Review
- The long noncoding RNAProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Use of Mass Cytometry to Profile Human T Cell Exhaustion.Frontiers in immunology · 2019Review
- According to Hepatitis C Virus (HCV) Infection Stage, Interleukin-7 Plus 4-1BB Triggering Alone or Combined with PD-1 Blockade Increases TRAF1Journal of virology · 2018Article
- The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1.Cell death and differentiation · 2017Article
- Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?Frontiers in immunology · 2017Review
- Current progress in the development of therapeutic vaccines for chronic hepatitis B virus infection.Iranian journal of basic medical sciences · 2016Review
- LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Regulation of Bim in Health and Disease.Oncotarget · 2015Review
- Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection.Nature medicine · 2015Article
- Double negative (DN) αβ T cells: misperception and overdue recognition.Immunology and cell biology · 2015Review
- Article
- Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection.Journal of virology · 2014Article
- The Fusion Protein of CTP-HBcAg18-27-Tapasin Mediates the Apoptosis of CD8(+)T Cells and CD8(+) T Cell Response in HLA-A2 Transgenic Mice.Hepatitis monthly · 2014Article
- Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics.Human vaccines & immunotherapeutics · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Apoptosis is critical for the development and maintenance of the immune system. The proapoptotic Bcl-2 family member Bim is important for normal immune system homeostasis. Although previous experiments have shown that Bim is critical for the apoptosis of antigen-specific CD8(+) T cells during acute viral infection, the role of Bim during chronic viral infection is unclear. Using lymphocytic choriomeningitis virus clone 13 infection of mice, we demonstrate a role for Bim in CD8(+) T-cell apoptosis during chronic viral infection. Enumeration of antigen-specific CD8(+) T cells by major histocompatibility complex class I tetramer staining revealed that CD8(+) D(b)NP396-404(+) T cells, which undergo extensive deletion in wild-type mice, exhibited almost no decrease in Bim mutant mice. This contrasts with CD8(+) D(b)GP33-41(+) and CD8(+) D(b)GP276-286(+) T cells that underwent similar decreases in numbers in both Bim mutant and wild-type mice. Increased numbers of CD8(+) D(b)NP396-404(+) T cells in Bim mutant mice were due to lack of apoptosis and could not be explained by altered proliferation, differential homing to tissues, or increased help from CD4(+) T cells. When viral titers were examined, high levels were initially observed in both groups, but in Bim mutant mice, clearance from the spleen and sera was slightly accelerated. These experiments demonstrate the critical role of Bim during chronic viral infection to down-regulate CD8(+) T-cell responses and have implications for designing strategies for optimizing immunotherapies during situations where antigen persists, such as chronic infection, autoimmune syndromes, and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.