ArticleGenes & development2006
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family.PloS one · 2026Article
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- Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans.PLoS biology · 2024Article
- ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.Genetics · 2023Article
- ZIF-1-mediated degradation of endogenous and heterologous zinc finger proteins in thebioRxiv : the preprint server for biology · 2023Article
- Article
- Role of zinc in female reproduction.Biology of reproduction · 2021Review
- ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.Science advances · 2020Article
- A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.Nature communications · 2019Article
- Cap-Independent mRNA Translation in Germ Cells.International journal of molecular sciences · 2019Review
- Article
- Zinc deficiency reduces fertility in C. elegans hermaphrodites and disrupts oogenesis and meiotic progression.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2017Article
- Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans.PloS one · 2017Article
- Post-transcriptional control of executioner caspases by RNA-binding proteins.Genes & development · 2016Article
- Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation.Oncotarget · 2016Article
- Programmed cell death and clearance of cell corpses in Caenorhabditis elegans.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- PtdIns(4,5)P₂ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance.The Journal of cell biology · 2015Article
- Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling.Biophysical journal · 2015Article
- An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.PLoS genetics · 2014Article
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10 authors at 3 institutions in 2 countries.
Funding
Abstract
During oocyte development in Caenorhabditis elegans, approximately half of all developing germ cells undergo apoptosis. While this process is evolutionarily conserved from worms to humans, the regulators of germ cell death are still largely unknown. In a genetic screen for novel genes involved in germline apoptosis in Caenorhabditis elegans, we identified and cloned gla-3. Loss of gla-3 function results in increased germline apoptosis and reduced brood size due to defective pachytene exit from meiosis I. gla-3 encodes a TIS11-like zinc-finger-containing protein that is expressed in the germline, from the L4 larval stage to adulthood. Biochemical evidence and genetic epistasis analysis revealed that GLA-3 participates in the MAPK signaling cascade and directly interacts with the C. elegans MAPK MPK-1, an essential meiotic regulator. Our results show that GLA-3 is a new component of the MAPK cascade that controls meiotic progression and apoptosis in the C. elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells.
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