ArticleRNA (New York, N.Y.)2006
Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Structural Insights into the Rrp4 Subunit from the Crystal Structure of theBiomolecules · 2024Article
- The Dynamic Network of RNP RNase P Subunits.International journal of molecular sciences · 2021Review
- Plant 3' Regulatory Regions From mRNA-Encoding Genes and Their Uses to Modulate Expression.Frontiers in plant science · 2020Review
- Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma.Oncology letters · 2019Article
- A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells.Genome biology and evolution · 2015Article
- Dis3- and exosome subunit-responsive 3' mRNA instability elements.Biochemical and biophysical research communications · 2012Article
- Review
- Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.Nucleic acids research · 2011Article
- Article
- The exozyme model: a continuum of functionally distinct complexes.RNA (New York, N.Y.) · 2011Review
- Defects in the secretory pathway and high Ca2+ induce multiple P-bodies.Molecular biology of the cell · 2010Article
- Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.PLoS biology · 2010Article
- Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.RNA (New York, N.Y.) · 2010Article
- Decoding ARE-mediated decay: is microRNA part of the equation?The Journal of cell biology · 2008Review
- RNA recognition by 3'-to-5' exonucleases: the substrate perspective.Biochimica et biophysica acta · 2008Review
- The exosome and RNA quality control in the nucleus.EMBO reports · 2007Review
- The exosome, plugged.EMBO reports · 2007Article
- RNA decay modulates gene expression and controls its fidelity.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have previously demonstrated that PM-Scl-75, a component of the human exosome complex involved in RNA maturation and mRNA decay, can specifically interact with RNAs containing an AU-rich instability element. Through the analysis of a series of deletion mutants, we have now shown that a 266 amino acid fragment representing the RNase PH domain is responsible for the sequence-specific binding to AU-rich elements. Furthermore, we found that the RNase PH domains from two other exosomal components, OIP2 and RRP41, as well as from Escherichia coli polynucleotide phosphorylase, are all capable of specifically interacting with RNAs containing an AU-rich element with similar affinities. Finally, we demonstrate that the interaction of the RNase PH domain of PM-Scl-75 is readily competed by poly(U), but only inefficiently using other homopolymeric RNAs. These data demonstrate that RNase PH domains in general have an affinity for U- and AU-rich sequences, and broaden the potential role in RNA biology of proteins containing these domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.