ArticleCancer research2006
Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma.
Article in Cancer research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays.Nature communications · 2022Article
- Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness.The oncologist · 2019Article
- Identification of copy number alterations in colon cancer from analysis of amplicon-based next generation sequencing data.Oncotarget · 2018Article
- Prediction of early-stage hepatocellular carcinoma using OncoScan chromosomal copy number aberration data.World journal of gastroenterology · 2017Article
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- Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).Breast cancer research and treatment · 2012Article
- Article
- Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- A molecular inversion probe assay for detecting alternative splicing.BMC genomics · 2010Article
- Molecular inversion probes reveal patterns of 9p21 deletion and copy number aberrations in childhood leukemia.Cancer genetics and cytogenetics · 2009Article
- High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays.BMC medical genomics · 2009Article
- Molecular inversion probe assay for allelic quantitation.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Connector inversion probe technology: a powerful one-primer multiplex DNA amplification system for numerous scientific applications.PloS one · 2007Article
- PathogenMip assay: a multiplex pathogen detection assay.PloS one · 2007Article
- Analysis of molecular inversion probe performance for allele copy number determination.Genome biology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Genomic instability is a major feature of neoplastic development in colorectal carcinoma and other cancers. Specific genomic instability events, such as deletions in chromosomes and other alterations in gene copy number, have potential utility as biologically relevant prognostic biomarkers. For example, genomic deletions on chromosome arm 18q are an indicator of colorectal carcinoma behavior and potentially useful as a prognostic indicator. Adapting a novel genomic technology called molecular inversion probes which can determine gene copy alterations, such as genomic deletions, we designed a set of probes to interrogate several hundred individual exons of >200 cancer genes with an overall distribution covering all chromosome arms. In addition, >100 probes were designed in close proximity of microsatellite markers on chromosome arm 18q. We analyzed a set of colorectal carcinoma cell lines and primary colorectal tumor samples for gene copy alterations and deletion mutations in exons. Based on clustering analysis, we distinguished the different categories of genomic instability among the colorectal cancer cell lines. Our analysis of primary tumors uncovered several distinct categories of colorectal carcinoma, each with specific patterns of 18q deletions and deletion mutations in specific genes. This finding has potential clinical ramifications given the application of 18q loss of heterozygosity events as a potential indicator for adjuvant treatment in stage II colorectal carcinoma.
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Registered trials
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