ArticleProceedings of the National Academy of Sciences of the United States of America2006
How to become a uropathogen: comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.
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167 citing papers in PubMed.
- Types I, II, V, and VI secretion system genes in clinical uropathogenicMicrobiology spectrum · 2026Article
- Mechanisms and clinical implications of bacterial persistence in recurrent urinary tract infections.Investigative and clinical urology · 2026Review
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- A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular Damage.bioRxiv : the preprint server for biology · 2025Article
- Role for RTX-family toxin HlyA of extraintestinal pathogenicFEMS microbes · 2025Article
- Differential perception of virulence factors of uropathogenicFrontiers in immunology · 2025Article
- Extraintestinal traits of pathogenicity and sequence type lineages in commensalFrontiers in microbiology · 2025Article
- Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy.Scientific reports · 2024Article
- Variable fitness effects of bacteriophage resistance mutations inJournal of virology · 2024Article
- Analysis of the partial sequencing of clbA, clbB and clbQ in Escherichia coli isolates that produce colibactin and multilocus sequence typing.Scientific reports · 2024Article
- Multidrug resistance in pathogenicFrontiers in veterinary science · 2024Article
- The Scr and Csc pathways for sucrose utilization co-exist inFrontiers in microbiology · 2024Article
- Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence.Nature communications · 2023Article
- The Escherichia coli Fur pan-regulon has few conserved but many unique regulatory targets.Nucleic acids research · 2023Article
- Stimulating Transcription in Antibiotic-Tolerant Escherichia coli Sensitizes It to Fluoroquinolone and Nonfluoroquinolone Topoisomerase Inhibitors.Antimicrobial agents and chemotherapy · 2023Article
- Emerging Non-Antibiotic Options Targeting Uropathogenic Mechanisms for Recurrent Uncomplicated Urinary Tract Infection.International journal of molecular sciences · 2023Review
- Distinct ecological fitness factors coordinated by a conservedProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Pathogenicity Islands in UropathogenicAntibiotics (Basel, Switzerland) · 2022Article
- Article
107 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Uropathogenic Escherichia coli (UPEC) strain 536 (O6:K15:H31) is one of the model organisms of extraintestinal pathogenic E. coli (ExPEC). To analyze this strain's genetic basis of urovirulence, we sequenced the entire genome and compared the data with the genome sequence of UPEC strain CFT073 (O6:K2:H1) and to the available genomes of nonpathogenic E. coli strain MG1655 (K-12) and enterohemorrhagic E. coli. The genome of strain 536 is approximately 292 kb smaller than that of strain CFT073. Genomic differences between both UPEC are mainly restricted to large pathogenicity islands, parts of which are unique to strain 536 or CFT073. Genome comparison underlines that repeated insertions and deletions in certain parts of the genome contribute to genome evolution. Furthermore, 427 and 432 genes are only present in strain 536 or in both UPEC, respectively. The majority of the latter genes is encoded within smaller horizontally acquired DNA regions scattered all over the genome. Several of these genes are involved in increasing the pathogens' fitness and adaptability. Analysis of virulence-associated traits expressed in the two UPEC O6 strains, together with genome comparison, demonstrate the marked genetic and phenotypic variability among UPEC. The ability to accumulate and express a variety of virulence-associated genes distinguishes ExPEC from many commensals and forms the basis for the individual virulence potential of ExPEC. Accordingly, instead of a common virulence mechanism, different ways exist among ExPEC to cause disease.
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