ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2006
Protein nitration with aging in the rat semimembranosus and soleus muscles.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide.Scientific reports · 2026Article
- In vitro immuno-prevention of nitration/dysfunction of myogenic stem cell activator HGF, towards developing a strategy for age-related muscle atrophy.Aging cell · 2024Article
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- The effects of buthionine sulfoximine treatment on diaphragm contractility and SERCA pump function in adult and middle aged rats.Physiological reports · 2015Article
- Identification of possible cigarette smoke constituents responsible for muscle catabolism.Journal of muscle research and cell motility · 2012Review
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- Mitochondrial longevity pathways.Biochimica et biophysica acta · 2011Review
- Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats.Experimental gerontology · 2010Article
- Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training.Journal of cachexia, sarcopenia and muscle · 2010Article
- Regulation of skeletal muscle mitochondrial function: genes to proteins.Acta physiologica (Oxford, England) · 2010Review
- Mechanisms behind estrogen's beneficial effect on muscle strength in females.Exercise and sport sciences reviews · 2010Review
- Mitochondrial function as a determinant of life span.Pflugers Archiv : European journal of physiology · 2010Review
- The energy-redox axis in aging and age-related neurodegeneration.Advanced drug delivery reviews · 2009Review
- Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Article
- A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Myosin and actin expression and oxidation in aging muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2006Article
- Mitochondrial DNA alterations and reduced mitochondrial function in aging.Mechanisms of ageing and developmentReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
On the basis of the accelerated age-related effects in type II muscle, we hypothesized that with aging the semimembranosus (type II) muscle would accumulate a greater amount of oxidized proteins compared to proteins in the soleus (type I) muscle. In this study, 3-nitrotyrosine (3-NT) was used as a stable marker of protein oxidative damage. The presence of 3-NT was evaluated in muscles from young adult, old, and very old Fischer 344 rats to provide an indication of the time course of muscle protein oxidative damage. A significant age-associated increase in nitrotyrosine-modified proteins was observed. The modified proteins identified by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry include the sarcoplasmic reticulum Ca(+2)-ATPase, aconitase, beta-enolase, triosephosphate isomerase, and carbonic anhydrase III. These proteins, involved in metabolism and calcium homeostasis, exhibited an age-dependent increase in 3-NT content in both muscles. However, significant levels of 3-NT modification were present at an earlier age in the semimembranosus muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.