Evidence map›Paper›PMID 16910656›Full record

ArticleJournal of the American Chemical Society2006

Selective sensing of metalloproteins from nonselective binding using a fluorogenic amphiphilic polymer.

Britto S Sandanaraj, Robert Demont, Sivakumar V Aathimanikandan, Elamprakash N Savariar, S Thayumanavan

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 69 citations in OpenAlex.

  1. Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. RAFT polymers for protein recognition.Beilstein journal of organic chemistry · 2010
    Article
  6. Enzyme-amplified array sensing of proteins in solution and in biofluids.Journal of the American Chemical Society · 2010
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Britto S SandanarajDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Robert Demont
Sivakumar V Aathimanikandan
Elamprakash N Savariar
S Thayumanavan
University of Massachusetts Amherst · US

Funding

New Amphiphillic Dendrimers for Encapsulation and ReleaseR01GM065255 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THAYUMANAVAN, SANKARAN · 2003 to 2019
$4.3M
NIGMS NIH HHS GM-65255NIGMS NIH HHS R01 GM065255
6 · The paper itself

Abstract

Nonconjugated fluorogenic amphiphilic polymers containing an anthracene chromophore exhibit fluorescence quenching in the presence of metalloproteins, although the binding of the polymer to proteins is not selective. The reason for this difference is that the possible conformational changes that protein binding could bring about on a polymer do not affect the fluorescence properties of a pendent chromophore in nonconjugated polymers. This is in contrast to the nonspecific binding and response found with conjugated polymers to proteins.

Indexed as

Fluorescent DyesMetalloproteinsMolecular StructurePolymersSpectrometry, FluorescenceSurface-Active AgentsFluorescent DyesMetalloproteinsPolymersSurface-Active Agents

Identifiers

PMID16910656
PMCPMC2515928
OpenAlexW1993599150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.