ArticleMolecular and cellular biochemistry2006
Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Activation of TP53 target genes in the primary response of triple-negative breast cancer cells to doxorubicin treatment.Scientific reports · 2025Article
- Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis.Scientific reports · 2019Article
- Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy.Cell death & disease · 2018Article
- Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis.Frontiers in physiology · 2018Review
- Senescent cells: an emerging target for diseases of ageing.Nature reviews. Drug discovery · 2017Review
- MiR-24-BIM-Smac/DIABLO axis controls the sensitivity to doxorubicin treatment in osteosarcoma.Scientific reports · 2016Article
- Review
- Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR.Nature protocols · 2015Article
- MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction.Oxidative medicine and cellular longevity · 2015Article
- Effect of Paris saponin I on radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line.Oncology letters · 2014Article
- Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.PloS one · 2014Article
- Article
- EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.PloS one · 2013Article
- Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma.Molecular medicine reports · 2012Article
- Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy.Cancer biology & therapy · 2011Article
- Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases.Cellular & molecular biology letters · 2010Article
- The phosphorylation status of merlin in sporadic vestibular Schwannomas.Molecular and cellular biochemistry · 2009Article
- Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.Biochimica et biophysica acta · 2008Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doxorubicin (DOX)-induced apoptosis is suppressed by p21 (waf1/cip1/sdi1), a cyclin dependent kinase (CDK) inhibitor. Here we show that exogenous expression of p21 before, but not after, the DOX-treatment protected p21-deficient human colorectal cancer cell line DLD1 from DOX-induced apoptosis. In previous work, we demonstrated that p21 inhibits DOX-induced apoptosis via its CDK-binding and CDK-inhibitory activity. Here we report that pre-existing p21 can associate with pro-caspase-3 and inhibit caspase-3 activation in the cells, which was at least in part responsible for enhancing survival of DOX-treated cells. Furthermore, the N-terminal domain of p21 was found to interact with pro-caspase-3 in DLD1 cells. Thus, we propose that pre-existing p21 is required to prevent DOX-induced apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.